High Resolution Chromatography Coupled Massspectrometer for Biomarker Discovery

临床研究小组对LMU蛋白质分析核心设施（Zentrallabor f<e:1> r Proteinanalytik, ZfP）蛋白质组学研究的兴趣日益浓厚，导致了临床蛋白质组学ZfP （ClinZfP）的建立。临床研究组对测量的高要求已不能满足现有仪器的要求。因此，临床生物标志物的检测（EXPLORE）和验证（CONFIRM）两种系统在此及相关应用中被要求。ZfP成为最近在慕尼黑建立的蛋白质组实验室网络（CLINSPECT-M）的成员，也说明了对临床蛋白质组学日益增长的兴趣，该网络旨在满足神经疾病质谱分析的医疗需求。CLINSPECT-M是德国联邦知识与研究部（BMBF）资助的四个小组之一，目的是在常规临床应用中建立质谱方法（https://www.gesundheitsforschung-bmbf.de/de/clinspect- m- clin临床-质谱-center-munchen-10979.php）。通过购买两台质谱仪，增加的测量能力将使BMC的ClinZFP能够使用CLINSPECT-M中建立的管道来解决其他临床问题，从而显着改善临床诊断和治疗的蛋白质组学研究

The increasing interest of clinical research groups in proteomic investigations at the Core facility for protein Analysis of the LMU (Zentrallabor für Proteinanalytik, ZfP) led to the establishment of ZfP for clinical proteomics (ClinZfP). The high demand for measurements requested from clinical research groups can no longer be met with the available instruments. For this reason, two systems for the detection (EXPLORE) and validation (CONFIRM) of clinical biomarkers are requested in this and the related application.This increasing interest in clinical proteomics is also illustrated by the ZfP's membership in the recently established network of proteome laboratories in Munich (CLINSPECT-M), which is intended to meet the medical need for mass spectrometry in neurological diseases. CLINSPECT-M is one of four clusters funded by the Federal Ministry of Knowledge and Research (BMBF) in Germany to establish mass spectrometric methods in routine clinical applications (https://www.gesundheitsforschung-bmbf.de/de/clinspect- m-clinical-mass-spectrometry-center-munchen-10979.php). The increased measuring capacity that would become available by the acquisition of two mass spectrometers applied for, would allow the ClinZFP at the BMC to use the pipelines set up in CLINSPECT-M for other clinical questions and thus significantly improve proteomic research for clinical diagnostics and therapy