High Resolution LC-MS System with Automated Samplepreparation for Biomarker Validation

临床研究小组对LMU蛋白质分析核心设施(ZFP)蛋白质组学研究的兴趣与日俱增，导致了临床蛋白质组学ZFP(ClinZfP)的建立。现有的仪器不能再满足临床研究小组对测量的高要求。由于这个原因，临床生物标志物的检测(探索)和确认(确认)两个系统被要求在这个和相关的应用中。这种对临床蛋白质组学日益增长的兴趣也从ZFP最近在慕尼黑建立的蛋白质组实验室网络(CLINSPECT-M)的成员资格中得到证明，该网络旨在满足神经系统疾病对质谱学的医疗需求。CLINSPECT-M是由德国联邦知识和研究部资助的四个集群之一，用于在常规临床应用(https://www.gesundheitsforschung-bmbf.de/de/clinspect-m-clinical-mass-spectrometry-center-munchen-10979.php).中建立质谱学方法通过购买两台申请的质谱仪，可以提高测量能力，这将使BMC的ClinZFP能够使用CLINSPECT-M中建立的管道来处理其他临床问题，从而显著改进用于临床诊断和治疗的蛋白质组研究。

The increasing interest of clinical research groups in proteomic investigations at the Core facility for protein Analysis of the LMU (Zentrallabor für Proteinanalytik, ZfP) led to the establishment of ZfP for clinical proteomics (ClinZfP). The high demand for measurements requested from clinical research groups can no longer be met with the available instruments. For this reason, two systems for the detection (EXPLORE) and validation (CONFIRM) of clinical biomarkers are requested in this and the related application.This increasing interest in clinical proteomics is also illustrated by the ZfP's membership in the recently established network of proteome laboratories in Munich (CLINSPECT-M), which is intended to meet the medical need for mass spectrometry in neurological diseases. CLINSPECT-M is one of four clusters funded by the Federal Ministry of Knowledge and Research (BMBF) in Germany to establish mass spectrometric methods in routine clinical applications (https://www.gesundheitsforschung-bmbf.de/de/clinspect- m-clinical-mass-spectrometry-center-munchen-10979.php). The increased measuring capacity that would become available by the acquisition of two mass spectrometers applied for, would allow the ClinZFP at the BMC to use the pipelines set up in CLINSPECT-M for other clinical questions and thus significantly improve proteomic research for clinical diagnostics and therapy.