The functional significance of the olivo-cerebellar input in obstacle avoidance during locomotion.

本研究的目的是探讨运动中橄榄-小脑通路损伤对避障的影响。结果如下：1)病变后动物在摇摆阶段表现为脚趾过度抬高，步幅缩短，膝关节和踝关节过度屈曲。2)在正常地面运动的损伤后动物中，股外侧肌在摇摆后期没有肌肉活动。在起飞时，股二头肌显示出肌肉活动。此外，腓肠肌在站立期和摆动后期分别表现出静止期和活动期的延长。3)在运动避障过程中，损伤后的动物表现为脚趾运动轨迹波动。本例中，避肢部分肌肉（股外侧肌、股二头肌、胫前肌和腓肠肌）表现出与病变前动物不同的活动。

The purpose of this study was to investigate the effect of lesions to the olivo-cerebellar pathway on obstacle avoidance during locomotion. The results are as follows. 1) The post-lesion animals showed excessive toe elevation, shortening stride length and hyper flexion of knee and ankle joints during the swing phase. 2) In post-lesion animals at normal ground locomotion, the vastus lateralis did not show muscle activity during the late swing phase. The biceps femoris showed muscle activity at lift-off. Moreover, the gastrocnemius showed prolongation of quiescent and active period during the stance phase and late swing phase, respectively. 3) In obstacle avoidance during locomotion, the post-lesion animals showed fluctuating toe trajectory. In this case, some muscle (the vastus lateralis, the biceps femoris, the tibialis anterior and the gastrocnemius) of avoiding limb showed different activity from pre-lesion animals.