Relationship between menopausal distress and serum estrogen, isoflavone and intake level of isoflavone

284名年龄在40-59岁之间的妇女参加了健康检查计划，完成了一份健康问卷，包括更年期痛苦的Kupperman测试。还通过半定量食物频率问卷对饮食进行了评估。在控制年龄和绝经状态后，发酵豆制品摄入量与潮热严重程度呈显著负相关（γ =-0.16，p = 0.01）。估计总豆制品和发酵豆制品的雌二醇摄入量降低了19%.We还分析了血清雌二醇（E2）和硫酸脱氢表雄酮（DHEAS）浓度和豆制品饮食摄入量与心理状态的横截面关系，采用流行病学研究中心抑郁量表（CES-D）和其他量表测量86名绝经后和绝经后日本妇女。血清DHEAS与QES-D量表呈负相关（γ =-0.22，p =-0.04）。豆制品摄入量与CES-D量表呈负相关（γ =-0.22，p =-0.04）。共有1，106名年龄在35-54岁的女性居民参与了高山研究，这是一项由我们设计的队列研究，她们都是绝经前的女性，并完成了一份经过验证的半定量食物频率问卷。根据Kupperman的说法，在6年的研究期间，101名女性出现了新的中度或重度潮热。在控制了年龄、总能量摄入量和绝经状态的数据后，潮热与豆制品摄入量呈负相关。我们还分析了上述受试者，发现在控制了年龄和总能量后，与最低三分位摄入量相比，第二个三分位摄入量与绝经前子宫切除术风险降低相关（率比= 0.35，95% CI = 0.13-0.97），尽管剂量-反应关系无统计学显著性。

284 women aged 40-59 years who attended a health check-up program completed a health questionnaire including the Kupperman test of menopausal distress. Diet was also assessed by a semiquantitative food frequency questionnaire. Fermented soy product intake was significantly negatively correlated with hot flush severity ( γ = -0.16, p = 0.01 ) after controlling for age and menopausal status. Estimated isoflavone intake from total and fermented soy products was lower by 19 %.We also analyzed the crosssectional relationships of serum concentrations of estradiol ( E2 ) and dehydroepiandrosterone sulfate ( DHEAS ) and dietary intake of soy products to psychological status measured by using Center for Epidemiologic Studies Depression Scale ( CES-D ) and other scales in 86 peri- and postmenopausal Japanese women. Serum DHEAS was inversely correlated with QES-D scale (γ = -0.22, p = -.04). Soy product intake was also inversely correlated with CES-D scale (γ = -0.22, p = -.04).A total of 1,106 female residents aged 35-54 years who were participants of the Takayama Study, a cohort study designed by us, and who were premenopausal and completed a validated semiquantitative food frequency questionnaire. During the 6-year study period, 101 women had new moderate or severe hot flashes according to the Kupperman. After data were controlled for age, total energy intake, and menopausal status, hot flashes were inversely associated with consumption of soy products.We also analyzed the subjects described above and found that the second tertile of isoflavone intake was associated with an decreased risk of premenopausal hysterectomy compared to the lowest tertile of intake after controlling for age and total energy ( rate ratio = 0.35, ,95 % CI = 0.13-0.97 ), although the dose-response relationship was not statistically significant.