Anticardiolipin Antibodies and Obstructive Vascular Events

抗磷脂抗体(抗心磷脂抗体(ACL)和狼疮抗凝剂(LA))患者经常出现动脉和/或静脉血栓形成、反复胎儿丢失和血小板减少。术语抗磷脂综合征(APS)被用来定义这一组病理特征。最近的证据表明，抗磷脂抗体可能参与了动脉粥样硬化病变的形成。在45岁以下的系统性红斑狼疮患者中，心肌梗死已被认为是主要的致死原因。我曾报道在AP患者中发现的aCL不是简单地针对CL结构，而是需要β2-糖蛋白I(β2GPI)的存在才能与之结合，其表位是通过β2GPI与氧取代的固体表面相互作用时发生的构象变化来表达的。1)抗心磷脂抗体的存在是血栓形成和动脉粥样硬化的危险因素。2)我们发现了β2GPI缺陷家族，命名为β2GPI-Sapporo。3)β2GPI基因多态性影响acl表位的形成和aCL的发生。

Arterial and/or venous thrombosis, recurrent fetal loss and thrombocytopenia are frequently found in patients with antiphospholipid antibodies (anticardiolipin antibodies (aCL) and lupus anticoagulant (LA)). The term antiphospholipid syndrome (APS) has been used to define this set of pathologic features.. Recent evidence suggested that antiphospholipid antibodies may have contributed to the formation of atherosclerotic lesions. In SLE less than 45 years of age, myocardial infarction has been recognized as a major cause of mortality.I have reported that aCL found in patients with APS are not simply directed to the CL structure, but require the presence of β2-glycoprotein I (β2GPI) for bindng and that the epitopes is expressed by conformational changes occurring when β2GPI interacts with an oxygen-substituted solid surface.I performed the reserch project, entitled "Anticardiolipin Antibodies and Obstructive Vascular Events" from 1999 to 2001 and obtained the following results ;1) Presence of anticardiolipin antibodies is risk factors for thrombus formation and atherosclerosis.2) We discovered the β2GPI-deficient families and named β2GPI-Sapporo.3) Genetic polymorphysm of β2GPI is influenced on the epitope formation of aCL and on the development of APS