Protective Effect of New Enteral Nutritional Formula including Whey Protein Hydrolysate against Indomethacin-Induced Ulceration in Rats

研究了一种含乳清蛋白水解物（WPH）的新型肠内营养配方对消炎痛所致溃疡的抑制作用。第一个实验导致接受皮下注射吲哚美辛或WPH配方喂养期的Sprague-Dawley雄性大鼠的肠溃疡出现率（1/7）低于喂食含有氨基酸（4/6）和完整蛋白质（6/7）作为氮源的配方的大鼠。实验二采用不同配方的饲料进行交叉喂养，结果表明，预喂WPH配方的大鼠出现肠溃疡的次数较少。（WPH前-WPH后为1/7，WPH-AA为1/8，AA-WPH为6/7，AA-AA为5/7）。在盲肠溃疡中也显示了类似的结果。这些结果表明，WPH配方将具有抑制吲哚美辛诱导的溃疡的某些特性。

A new enteral nutritional formula containing whey protein hydrolysate (WPH) was evaluated its suppressive effect on indomethacin-induced ulcers. The first experiment resulted less intestinal ulcers appearance (1/7) in Sprague-Dawley male rats which received subcutaneous indomethacin administration or WPH formula feeding period than in those fed the formulas containing amino acids(4/6) and intact protein (6/7) as nitrogen source. In the second experiment, rats were cross-fed on different formulas, less intestinal ulcers appeared in rats pre-fed WPH formula. (1/7 in pre WPH- post WPH, 1/8 in WPH-AA, 6/7 in AA-WPH, 5/7 in AA-AA). Similar results were also shown in cecum ulcers. These results suggest that the WPH formula would have some property suppressing indomethacin-induced ulcers.