Hemodynamics of chronic venous hypertension in rat

观察慢性静脉性高血压大鼠局部脑静脉血流量(RCBF)和脑血容量(RCBV)的变化。采用右侧颈动脉与右侧颈外静脉端到端吻合的方法建立静脉高压模型，分别于吻合前、吻合后、吻合后2周、瘘口夹闭后4次，用现代激光多普勒“扫描”技术测定25个部位的局部脑血流量(1CBF)和1CBV。动物分为两组：假手术组(n=6)(仅阻断颈动脉)和搭桥组(n=10)。假手术组和转流组左侧大脑半球rCBF和rCBV均无明显变化。而右侧大脑半球rCBV在搭桥后2周显著增加，夹闭后恢复(P&lt；0.05)，rCBF在搭桥后2周显著降低，夹闭后恢复(P&lt；0.05)。结论：大鼠颈动脉-颈静脉动静脉瘘模型具有临床意义，可用于慢性静脉高压的病理生理研究。静脉缺血是一种可逆的状态，通过适当的早期治疗可以改善。

We evaluated changes of regional cerebral venous flow (rCBF) and cerebral blood volume (rCBV) in chronic venous hypertension model in rat. Venous hypertension was induced by an end-to-end anastomosis between the right carotid artery and the right external jugular vein.Local CBF (1CBF) and 1CBV at 25 locations were assessed by a modern laser Doppler "scanning" technique at 4 times ; before and after the anastomosis, 2 weeks after, and after the clip of the fistula. The animals were classified two groups ; sham-operated group (n = 6) (the carotid artery occlusion only) and bypass group (n = 10). In the sham group and the left hemisphere of the bypass group, both of rCBF and rCBV didn't change. However, in the right hemisphere rCBV significantly increased 2 weeks after the bypass but recovered after clipping of the fistula (p < 0.05), and rCBF significantly decreased 2 weeks after the bypass but recovered after clipping of the fistula (P < 0.05).In conclusion, the rat model of carotid-jugular arteriovenous fistula is clinically relevant and useful for studing the pathophysiology of chronic venous hypertension. Venous ischemia is a reversible condition which can be improved by appropriate early-stage treatment.