Action Mechanism of Stress in the Higher Brain Mechanisms and Modulation of Sedation

应激认知和情绪表现是由复杂的脑神经网络机制形成的高级脑功能。使用微量透析法检测选择性抗焦虑药、选择性镇静剂和苯并氮卓类药物对这些高级脑功能的影响。结果表明，选择性抗焦虑药、选择性镇静剂和苯基安定对蓝斑(LC)-前额叶皮质(PFC)去甲肾上腺素神经活动和腹侧被盖区(VTA)-伏核(N.Acc)有不同的作用。多巴胺神经活动。应激状态下去甲肾上腺素神经活动和VTA-N.Acc。苯二氮卓类药物控制的多巴胺神经活动。选择性抗焦虑药仅控制LC-PFC去甲肾上腺素的神经活动。选择性镇静剂仅控制VTA-N。行政协调会。多巴胺神经活动。选择性抗焦虑药和选择性镇静剂对大脑神经网络的作用不同，选择性抗焦虑药和选择性镇静剂表现为肌肉松弛作用，不同于苯并盖氮系统药物，起源于LC，未见出现。对于选择性抗焦虑药和选择性镇静剂，对上呼吸道阻塞和抑制呼吸的作用较小。认为其原因是源于LC的肌肉松弛作用不明显。

The stress cognition and the emotional appearance are the higher brain functions formed with complex brain neural network mechanisms. The influence of selective anxiolytics, selective sedatives, and benzogeazepins to these higher brain functions, were examined used with microdiaiysis. The load time of the stress, and these drugs, laboratory animal in no anesthetizing, unrestraint, and the state of the freely moving were examined from the movement of the neurotransmitters in the brain when administering them.As a result, it was shown that selective anxiolytics, selective sedatives, and benzogeazepins had different actions for the locus coeruleus (LC) - prefrontal cortex (PFC) norepinephrine nerve activity and ventral tegmental area (VTA) - nucleus accumbens (N.Acc.) dopamine nerve activity. Both of the norepinephrine nerve activity in the state of stress and VTA- N.Acc. dopamine nerve activity controlled by benzodiazepines. Selective anxiolytics controlled only the LC-PFC norepinephrine nerve activity. Selective sedatives controlled only the VTA-N. Acc. dopamine nerve activity. Differed the action on the neural network in the brain taking part in the selection of an anxyolytic action and sedative actionSelective anxiolytics and the selective sedatives showed the muscle relax action which differed from benzogeazepin system medicine, and originated in LC and it was shown not to appear. As for selective anxiolytics and selective sedatives have a few effect of the upper airway obstruction and depress breathing . It was thought that there was no muscle relax action which originated in LC as the reason.