Construction of Molecular Devise using Metal Complex-type Artificial DNA 60187333

DNA具有排列功能化构件的结构基础。在这项研究中，1 ~ 5个Cu^<2+>介导的羟基吡啶酮核碱基碱基对被系统地整合到DNA双链体的中间，导致DNA螺旋内堆积的单核至五核Cu^<2+>配合物形成磁性链。每个络合物中的Cu^2+离子通过未成对的d电子相互铁磁耦合。提出了一种DNA中具有Cu^<2+>阵列的右手双链结构的轮廓，其中Cu^<2+>-Cu^<2+>距离几乎与天然碱基对之间的距离相同。这种策略代表了一种以离散和可预测的方式在溶液中排列金属离子的新方法，并与其他非生物方法形成对比，从而导致基于金属的分子器件如分子磁体和导线的可能性。

DNA has a structural basis to array functionalized building blocks. In this study, one to five Cu^<2+>-mediated base pairs of hydroxypyridone nucleobases have been systematically incorporated into the middle of a DNA duplex, resulting in the formation of a magnetic chain by the line-up of mono- to pentanuclear Cu^<2+> complexes stacked within the DNA helix. The Cu^<2+> ions in each complex couple ferromagnetically with one another through unpaired d electrons. An outline of a right-handed, double-stranded structure with Cu^<2+> array inside the DNA is proposed, where the Cu^<2+>-Cu^<2+> distance is almost the same as that between natural base pairs. This strategy represents a new method for arranging metal ions in solution in a discrete and predictable fashion and contrasts with the non-biological approach of others, leading to the possibility of metal-based molecular devices such as molecular magnets and wires.