On health-promoting effects of resistance training

在本研究项目中，研究了大鼠和人的抗阻训练对健康的促进作用。在第一个实验中，我们检测了阻力训练是否影响大鼠足底肌肉解偶联蛋白3的表达。阻力训练组大鼠通过爬1米高的笼子取水进行阻力训练。结果表明，解偶联蛋白3的表达不受抗阻训练的影响。实验二，研究抗阻训练对大鼠血液中碳水化合物/脂肪代谢相关物质及脂肪细胞因子水平的影响。阻力训练和第一次实验一样。阻力训练显著降低附睾、腹膜后和腹股沟脂肪垫重量。抗阻训练对血清脂肪细胞因子水平也有不同的影响，血清瘦素浓度显著降低，血清TNF-α、脂联素和抵抗素浓度无显著变化。抗阻训练显著降低了血清胰岛素浓度，但对血糖浓度没有影响，说明抗阻训练改善了胰岛素敏感性。第三个实验检验了不同运动强度的急性抵抗运动是否会对男性血清脂肪细胞因子水平产生不同的影响。受试者进行深蹲、旋臂、推腿、拉身、伸腿、卧推，强度最大为1次重复的20%或60%。在控制条件下，受试者不进行任何运动。结果表明，急性抵抗运动不影响血清瘦素和脂联素浓度。

In the present study project, health-promoting effects of resistance training were investigated in rats and humans. In the first experiment, we examined if the resistance training affected uncoupling protein 3 expression in the plantar is muscles of rats. The rats of a resistance training group performed resistance training by climbing 1-m high cages for access to water. The results indicated that the expression of uncoupling protein 3 was not altered by the resistance training. In the second experiment, the effects of the resistance training on carbohydrate/fat metabolism-related substance and adipocytokine levels in the blood were studied in rats. The resistance training was the same as that of the first experiment. The resistance training significantly decreased the epididymal, retroperitoneal, and inguinal fat pad weights. The resistance training also induced differential effects on the serum adipocytokine levels with a significant decrement of the serum leptin concentration and no significant changes in the serum TNF-α, adiponectin, and resistin concentrations. A significantly lower serum insulin concentration was observed in the resistance training with no effect on the plasma glucose concentration, which suggest that the resistance training improved insulin sensitivity. The third experiment examined if acute resistance exercises varying in exercise intensity induced differential effects on serum adipocytokine levels in men. The subjects performed squat, arm curl, leg press, pull over, leg extension and bench press with the intensities of 20% or 60% of one repetition maximum. In the control condition, the subjects did not perform any exercise. It was shown that acute resistance exercises did not affect the serum leptin and adiponectin concentrations.