Asymmetric reactions controled with moleculary imprinted polymers.

以双环手性氨基醇为模板合成了分子印迹聚合物。通过高效液相分析检测了模板分子与其他氨基醇分子与聚合物亲和力的差异，观察到模板分子的选择性吸附。此外，模板氨基醇对印迹聚合物的吸附优先于其对映体，考察了模板分子与模板分子的不对称反应。磺胺类、噻唑类和硫醚类双环骨架化合物分别被成功地用于酮的氢转移还原反应、Diels-Alder反应和π-烯丙基烷基化反应。这些化合物不仅表现出高产率和良好的选择性，而且具有不受底物空间体积影响的奇特特性，由于这些基本特性和限制构象，这些催化剂可能是很好的印迹聚合物模板。印迹聚合物在这些不对称反应中的应用还需要进一步的研究。

Molecularly imprinted polymers were synthesized by use of bicyclic chiral aminoalcohols as template. The difference of affinities between the template molecule and other aminoalcohols to the polymers were detected by HPLC analysis, selective adsorbtion of templete molecule were observed. Moreover, the templete aminoalcohols showed priority in adosorbtion to the imprinted polymer over its enantiomer.Asymmetric reactions with template molecules as catalysts were examined. Sulfonamides, thiazolines and thioethers with bicyclic skeleton were successfully utilized in hydrogen-transfer reduction of ketones, the Diels-Alder reactions and π-allyl alkylations, respectively. These compounds showed not only high yields and excellent selectiveties but marvelous character that cannot be affected by sterically bulkyness of substrate.These catalysts might be good templetes of imprinted polymers because of these basic characters and restricted conformations. Further investigations will be needed for application of the imprinted polymers to these asymmetric reactions.