Spezifische und überlappende Funktionen der Kollagen-bindenden Integrinrezeptoren in der Haut

胶原结合整合素受体有助于维持富含胶原蛋白的组织的结构完整性，例如皮肤真皮。其中3种受体：整合素α1β1、α2β1和α11β1在真皮成纤维细胞和内皮细胞中均有不同程度的表达，而表皮角质形成细胞仅表达α2β1。结合使用突变的成纤维细胞和内皮细胞的体外补充功能分析，这项工作将有助于识别皮肤中独特的和重叠的受体功能。

Collagen-binding integrin receptors are instrumental in maintaining the structural integrity of tissues rich in collagen, e.g. the dermis of the skin. Three of these receptors, integrins α1β1, α2β1 and α11β1, are expressed at varying levels by fibroblasts and endothelial cells in the dermis, while epidermal keratinocytes only express α2β1. Mice deficient for either one or two receptors will be subjected to conditions challenging the functions mediated by the integrins. Together with complementary in vitro functional assays using mutant fibroblasts and endothelial cells, this work will contribute to identifying unique and overlapping receptor functions in skin.