SP9: Generalizing predictive patterns of treatment (non-) response: from specific phobia and obsessive-compulsive disorder to the anxiety spectrum

焦虑症和强迫症(OCD)高度并存，反映在神经结构和功能部分重叠。虽然在当前的分类系统中，强迫症被从焦虑部分中删除，但这些障碍的认知行为治疗(例如，暴露)非常相似。共性，但也有不同，因此很少被理解，包括神经系统水平。SP9项目旨在研究与治疗反应相关的神经结构和功能可以在多大程度上从病理性恐惧的特定恐惧症概括到其他更复杂的焦虑症和相关情况(社交焦虑症、恐慌症、广场恐惧症、广泛性焦虑症和创伤后应激障碍)。其次，将通过比较强迫症和焦虑症之间的签名和预测来检验强迫症单独分类的经验证据。SP9将利用两个回顾数据集(SpiderVR研究：n=174名蜘蛛恐惧症患者；EPOC-研究：n=116名强迫症患者)来训练预测模型，这些模型将在研究单位的预期队列中复制/交叉验证。所有数据集共享一个公共的神经成像主干，包括神经解剖数据、静息状态网络(EEG、fMRI)和基于任务的活动和连接性，这些将被用于研究概化梯度。结果将有可能从跨诊断的角度更好地理解NR的现象，并帮助指导干预决策。

Anxiety disorders and obsessive-compulsive disorders (OCD) are highly comorbid, which is reflected in partly overlapping neural structure and function. Although OCD was removed from the anxiety section in current classification systems, cognitive-behavioral treatments (e.g., exposure) for these disorders are quite similar. Commonalities, but also differences are hence poorly understood, including a neural systems level. Project SP9 aims to investigate the hypothesis to which extent neural structure and function related to treatment response can be generalized from specific phobia as a “model” disorder for pathological fear to other, more complex anxiety disorders and related conditions (social anxiety disorder, panic disorder, agoraphobia, generalized anxiety disorder and posttraumatic stress disorder). Second, empirical evidence for the separate classification of OCD will be tested by comparing signatures and predictions between OCD and the anxiety spectrum. SP9 will utilize two retrospective datasets (SpiderVR-study: n = 174 spider phobia patients; EPOC-study: n = 116 OCD patients) in order to train predictive models which in turn will be replicated / cross-validated in the prospective cohort from the research unit. All datasets share a common neuroimaging backbone comprising neuroanatomic data, resting-state networks (EEG, fMRI) and task-based activity and connectivity which will be used to investigate generalization gradients. Results will bear potential to better understand the phenomenon of NR from a transdiagnostic perspective and to help guiding intervention decisions.