cell cycle regulation

信号转导通路中的MAP激酶级联：MAP激酶已被确定为诱导磷酸化激活由cdc2和细胞周期蛋白组成的成熟促进因子（MAF）的激酶。nishida （Kyoto U.）和Sakata （Kyushu U.）博士阐明，Mos是MAP激酶级联的关键调节因子。S期DNA复制许可因子的鉴定：在真核生物中，整个基因组DNA在S期只复制一次是非常重要的。为了做到这一点，假设细胞拥有一个因子，只允许在S期DNA复制的信号轮。在这个研究项目中，takisawa博士发现了允许单轮DNA复制的蛋白质因子。它被证明是一种哺乳动物同源的s.e cereviae Mcm家族。细胞周期中的周期蛋白：周期蛋白由MPF或SPF与cdc2或cdks组成，它们被称为细胞周期引擎。在这种情况下，为什么周期蛋白对强积金和SPF功能至关重要是一个非常重要的问题。Kobayashi博士（Kyushu U.）和Kishimoto博士（Tokyou Engineering U.）研究了G2/M过渡期间cdc2和cyclin B之间的相互作用。细胞周期中的泛素系统：蛋白质的降解依赖于泛素或非泛素周期。在细胞周期中，泛素依赖性蛋白的降解对细胞周期的进行具有重要意义。它在调节细胞周期进程中也起着重要的作用。田中博士（Tokushima U.）已经鉴定出含有泛素依赖性蛋白酶体的蛋白质，并克隆了编码这些蛋白质的cDNA。细胞周期中的G蛋白：一个小的G蛋白起着生物开关的作用。目前已发现许多G蛋白参与了信号转导和蛋白分泌。RCC1是由nishimoto博士（九州大学）的团队克隆的，它作为一个小核GTP酶Ran的GTP/GDP交换因子。由于RCC1的缺失导致有丝分裂的过早开始，因此RCC1被认为较少参与细胞周期调节

MAP kinase cascade in the signal transduction pathway : Map kinase has been identified as a kinase which induce phosphorylation to activate maturation prompting factor (MAF) consisting of cdc2 and cyclin B.Drs.Nishida (Kyoto U.) and Sakata (Kyushu U.) clarified that Mos is a key regulator in the MAP kinase cascade.Identification of Licensing factor for DNA replication in S phase : In eukaryote, it is very important that the total genomic DNA is replicated only once in the S phase. To do that it has been assumed that cells possess a factor to license only the signal round of DNA replication in S phase. In this research program, Dr.Takisawa identified the protein factor which allow a single round of DNA replication. It is turned out to be a mammalian homologue of S.cereviae Mcm families.Cyclins in the cell cycle : Cyclins comprise either MPF or SPF with cdc2 or cdks that are so called cell cycle engines. In this context, it is a very important question why cyclins are essential for MPF a … More nd SPF functions. Drs Kobayashi (Kyushu U.) and Kishimoto (Tokyou Engineering U.) investigated the interaction between cdc2 and cyclin B during G2/M transition.Ubiqutin system in the cell cycle : Degradation of proteins depend on either ubiqutin or nonubiqutin cycle.in the cell cycle, the ubiqutin dependent protein degradation is important for the progression of cell cycle. It plays a impartant role for the regulation of cell cycle progression either. Dr.Tanaka (Tokushima U.) has identified proteins comprising the ubiqutin dependent proteasome and cloned the cDNA encoding these proteins.G protesin in the cell cycle : A small G protein functions as a biological switch. Thus far, many G proteins have been found to be involved in the signal transduction and the protein secretion. RCC1 which was cloned by the group of Dr.Nishimoto (Kyushu U.) functions as a GTP/GDP exchanging factor for a small nuclear GTPase Ran.Since loss of RCC1 induces premature initiation of mitosis, RCC1 is assumed to be involved in the cell cycle regulation Less