Analysis on the relationship between longevity-associated mitochondrial DNA polymorphism, HLA type, lifestyle, and health condition

据报道，线粒体DNA 5178胞嘧啶/腺嘌呤（Mt5178 C/A）多态性与日本人的寿命有关。Mt5178A基因型在日本百岁老人中的频率明显高于一般人群，据报道，与Mt5178C基因型相比，Mt5178A基因型的个体对2型糖尿病、心肌梗死和脑血管疾病（恶性肿瘤除外）等成人发病疾病的易感性较低。Mt5178A基因型可能具有抗动脉粥样硬化作用。我们报道了Mt5178 C/A多态性还与血压、血脂水平、空腹血糖水平和葡萄糖耐量、血清尿酸水平、眼压、血液学参数、血清蛋白分数水平和血清电解质水平相关。报告了Mt5178 C/A多态性与习惯性饮酒对血压、血清甘油三酯水平、空腹血糖水平和葡萄糖耐量、血清尿酸水平和眼压的相互作用。Mt5178 C/A多态性与习惯性吸烟血清甘油三酯水平、血清总胆固醇水平、血清低密度脂蛋白胆固醇水平、红细胞计数、眼压和血清蛋白分数水平的相互作用也被报道。其中一些相互作用可能随着身体质量指数而变化。基于Mt5178 C/A基因型的个人饮酒和/或吸烟习惯的改变可能会改善健康状况，如血压、血脂水平、空腹血糖水平和葡萄糖耐量以及血清尿酸水平。进一步研究Mt5178 C/A多态性与健康状况的关系，可能有助于建立个性化的生活方式相关疾病预防策略。

Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism is reportedly associated with longevity in Japanese. The frequency of the Mt5178A genotype is significantly higher in Japanese centenarians than in the general population and it is reported that individuals with Mt5178A are less susceptible to adult-onset diseases, such as type 2 diabetes, myocardial infarction and cerebrovascular disorders, except malignancy, than those with Mt5178C. Mt5178A genotype may exert antiatherogenic effect. We reported that Mt5178 C/A polymorphism is also associated with blood pressure, serum lipid levels, fasting plasma glucose levels and glucose tolerance, serum uric acid levels, intraocular pressure, hematological parameters, serum protein fraction levels, and serum electrolyte levels. Interactions between Mt5178 C/A polymorphism and habitual drinking on blood pressure, serum triglyceride levels, fasting plasma glucose levels and glucose tolerance, serum uric acid levels and intraocular pressure were reported. Interactions between Mt5178 C/A polymorphism and habitual smoking serum triglyceride levels, serum total cholesterol levels, serum low-density lipoprotein cholesterol levels, red blood cell counts, intraocular pressure and serum protein fraction levels were also reported. Some of these interactions may vary with body mass index. Individual modification of drinking and/or smoking habits based on Mt5178 C/A genotype may improve health conditions, such as blood pressure, serum lipid levels fasting glucose levels and glucose tolerance, and serum uric acid levels. Further investigation into the association between Mt5178 C/A polymorphism and health status may contribute to the establishment of personalized prevention strategies for lifestyle-related diseases.