Biocontrol of reactive oxygen species produced by uranium and the analysis of chemical toxicity of depleted uranium.

近年来，在海湾战争、阿富汗战争和伊拉克战争等地区问题上大量使用贫铀弹已成为国际社会的严重问题。众所周知，铀和钚一样，除了辐射作用外，还具有很强的化学毒性。从铀弹伤亡恢复和原子能安全的角度分析铀化学毒性机理具有重要意义。2004 ~ 2006年，为了分析贫铀的化学毒性，采用自旋俘获法研究了氨基酸、糖类、抗氧化剂等多种生物物质对铀-过氧化氢体系中羟基自由基的消除动力学。研究了反应特性，特别是新自旋陷阱、CYPMPO的氧化，以及油溶性抗氧化剂对体系中羟基自由基形成的影响。利用ESR流动注射系统进行了动力学分析。为了分析羟基自由基在动物体内形成的影响，采用微透析法分析了大鼠脑内氧化还原酶的状态。此外，还分析了在儿茶素和单宁存在的情况下贫铀对DNA的破坏。在此基础上，讨论了铀在生物系统中的化学毒性与铀-过氧化氢体系中活性氧生成的关系。这些研究结果发表在11种科学期刊上，在5次国际会议上提出，在21次国内会议上提出。

Recently, it becomes the international serious problems that so many depleted uranium bombs were used at the area troubles, such as the Gulf War Afghanistan trouble and Iraq War. It is well known that uranium, as same as plutonium, has strong chemical toxicity beside its radiation effects. It is very important to analyze the mechanism of the uranium chemical toxicity on the stand point of the recovery of the U-bomb casualties and the safety of atomic energy. From 2004 to 2006, to analyze the chemical toxicity of depleted uranium, the kinetics of the elimination of hydroxyl radical in uranium-hydrogen peroxide system by several biosubstances, such as amino acids, saccharides, anti-oxidants had been studied by spin trapping method. Reaction characteristics, especially oxidation of new spin traps, CYPMPO, and the effect of oil-soluble anti-oxidants on the formation of hydroxyl radical in the system had been also examined. Kinetics using the ESR flow-injection system had been analyzed. To analyze the effect of hydroxyl radical formation in animal bodies, the red0ox state in rat brain had been analyzed using the microdialysis method. Furthermore, DNA breakage by depleted uranium under existence of catechins and tannins had been analyzed. Summarizing these results, the relationship between the chemical toxicity of uranium in biosystem and the formation of reactive oxygens in uranium-hydrogen peroxide system was discussed. These results were published as 11 scientific journals, presented as 5 International Congress, and 21 domestic meetings.