Coordination Funds

肥胖是一种非传染性的广泛性疾病。它增加了患2型糖尿病、高血压、脂代谢紊乱和其他合并症的风险。肥胖症在人口中的高流行率造成了巨大的医疗费用，因为患者普遍受到大规模健康限制，死亡率增加。然而，长期有效的持续减肥和对新陈代谢的积极影响仍然是不可用的。通过明确的生活方式干预措施，如限制卡路里和/或运动训练，短期内成功减肥，显示出相当大的个体差异。在生活方式干预过程中识别这些代谢型的生物标记物及其代谢适应以保护身体脂肪储存，将有助于在早期阶段发现这些适应的开始，并针对每个人适当调整干预的类型和强度。研究组旨在进一步开发和应用基于光声学和磁共振的新的非侵入性成像技术，以安全和纵向地监测能量和脂肪代谢的参数，特别是体内脂肪组织和肌肉。这包括动态测量血红蛋白(氧合/脱氧)、血氧饱和率、血容量和流速、脂谱以及细胞和组织中的脂类和水分含量。在对肥胖、胰岛素抵抗和糖尿病参与者进行的初步研究中，我们将记录和分析这些参数在急性代谢挑战(测试餐、寒冷暴露、训练)期间的动态反应，以确定个别代谢类型的生物标记物。我们将在一项限制卡路里或运动训练的干预性研究中使用和评估新的成像技术，以检测和纵向监测选定的生物标志物。特别是，我们感兴趣的生物标记物反映了干预过程中肌肉和脂肪组织的代谢适应，并与全身代谢状态的积极变化有关。我们的研究单位将调查这些生物标记物对个性化生活方式干预的适用性。长期目标是通过对当前代谢状态的无标签测量来开发新的诊断方法，这将为治疗超重和肥胖的个性化营养和药物创造新的可能性。

Obesity is one of the non-communicable widespread diseases. It increases the risk of developing type 2 diabetes, high blood pressure, lipometabolic disorders, and other comorbidities. The high prevalence of obesity in the population causes significant health care costs due to widespread massive health restrictions in patients and increased mortality. However, long-term effective therapy for sustainable weight reduction and positive influence on the metabolism is still not available. Short-term successful weight loss through defined lifestyle interventions, such as caloric restriction and/or exercise training, shows considerable individual variation. The identification of biomarkers for these metabotypes and their metabolic adaptations to defend body fat stores in the course of lifestyle interventions would help to detect the onset of these adaptations at an early stage and appropriately adjust the type and intensity of the interventions for each individual.The Research Unit aims to further develop and apply new non-invasive imaging technologies based on optoacoustics and magnetic resonance for safe and longitudinal monitoring of parameters of energy and lipid metabolism, in particular in adipose tissue and muscle in vivo. This includes dynamic measurements of hemoglobin (oxygenated/deoxygenated), oxygen saturation rate, blood volume and flow rate, lipid profiles, as well as lipid and water content in cells and tissues. In pilot studies with participants with obesity, insulin-resistance and diabetes we will record and analyze the dynamic responses of these parameters during acute metabolic challenges (test meal, exposure to cold, training) in order to identify biomarkers for individual metabotypes. We will use and evaluate the new imaging technologies for detection and longitudinal monitoring of selected biomarkers in an intervention study with caloric restriction or exercise training. In particular, we are interested in biomarkers that reflect metabolic adaptations in muscle and fat tissue during the course of the intervention and are associated with positive changes in the systemic metabolic status. Our Research Unit will investigate the suitability of such biomarkers for personalizing lifestyle interventions. The long-term goal is the development of new diagnostic approaches through label-free measurement of the current metabolic status, which will create new possibilities in personalized nutrition and medicine for the treatment of overweight and obesity.