A long-term follow-up study on the relationship of social and lifestyle factors in childhood to cardiovascular risk factors in adulthood

据多次报道，低出生体重与不利的心血管危险因素以及成年后心血管疾病的发病率和死亡率有关。然而，出生前后的社会和生活方式因素是否会影响这种关系还没有得到充分的调查。这是一项对5000名男性和女性进行的为期20年的随访研究，旨在调查出生时和童年时的社会和生活方式因素与20岁时心血管风险因素（血压、血清胆固醇和体重指数）的关系。从1965-1974年出生的婴儿中获得了有关社会因素（年龄、教育和父母的职业；住房等）和生活方式因素（母乳喂养等）的信息。这些信息与他们20岁时的健康检查数据相关联。主要结果如下：(1)出生体重与20岁时血压呈显著负相关，父亲教育程度的调整减弱了这一负相关。(2)男性出生体重与20岁血清胆固醇呈显著负相关关系，但社会因素的调整没有改变。(3)在男性中，母亲受教育程度较低与20岁时血压升高有关。(4)男性童年时期与祖父、祖母生活在一起与20岁时血压升高有关。(5)男性出生时母亲年龄在35岁及以上，且母亲受教育程度较高，其20岁时胆固醇水平较低。(6)主要由祖母抚养长大的女性在20岁时胆固醇水平较高。结果表明，出生体重与成年期心血管危险因素的关系受出生时和童年期一些社会因素的影响，而成年期一些社会因素与心血管危险因素独立相关。

Lower birth weight has been repeatedly reported to be related to adverse cardiovascular risk factors and cardiovascular disease morbidity and mortality in adulthood. However, it has not been fully investigated whether social and lifestyle factors before and after birth affect this relationship. This is a 20-year follow-up study in 5,000 men and women to investigate the relationship of social and lifestyle factors at birth and in childhood to cardiovascular risk factors (blood pressure, serum cholesterol, and body mass index) at the age of 20.Information on social factors (age, education, and occupation of mother and father ; housing, etc.) and lifestyle factors (breast feeding, etc.) were obtained in babies who were born in 1965-1974. The information was linked to health examination data at the age of 20.Main results were : (1)A significant inverse relationship between birth weight and blood pressure at 20 years was attenuated by adjustment of education of father. (2)A significant inverse relationship between birth weight and serum cholesterol at 20 years in men did not change by adjustment of social factors. (3)In men, lower education of mother was related to higher blood pressure at 20 years. (4)In men, living with grand father and grand mother in childhood was related to higher blood pressure at 20 years. (5)In men, having mother aged 35 or over at birth and mother with higher education was related to lower cholesterol at 20 years. (6)Women who were grown up mainly by grand mother had higher cholesterol at 20 years.The results showed that the relationship between birth weight and cardiovascular risk factors in adult life was affected by some social factors at birth and in childhood, and that some social factors were independently related to cardiovascular risk factors in adulthood.