the maintenance and circulation of protein higher-order structural information and the evaluation of prediction information

我们主要通过以下三年的研究产品和活动，进行了蛋白质高阶结构信息的维护和流通以及预测信息的评价。我们每年都会举办“基于蛋白质高阶结构（高阶基因组）的基因组信息科学”公开研讨会，包括“高阶基因组”小组的海报展示和为期一天的研讨会。第一年，我们邀请了两位来自蛋白质结构和生物信息学领域的海外演讲者，并举办了一次国际研讨会。第二年，随着结构基因组学的快速发展，为迎接即将到来的高级结构信息洪流，我们举办了题为“信息生物学即结构基因组科学——当代表性蛋白质的所有蛋白质结构都得到澄清——”的公开研讨会，加强了与结构生物学家的合作。基因组信息的解码将是不完整的……如果不了解蛋白质，对生理现象起直接作用的主要参与者，模拟研究作为实现这一目标的手段占据重要地位。第三年，我们举办了题为“前沿生物信息学——模拟能在多大程度上阐明蛋白质功能？”的国际研讨会，邀请了4位海外研究人员。作为2000年国际结构基因组学会议（ICSG）的卫星会议，还举办了“计算结构基因组学一天研讨会”。此外，我们还开展了“高阶基因组”小组的研究会议、支持青年研究人员的研究会议、支持参加“蛋白质结构预测技术关键评估（CASP）”国际会议的差旅以及与藻类研究人员在“基因组生物学”方面的合作。另一方面，我们对GTOP数据库中公开发布为FAMSBASE （http://daisy.nagahama-i-bio.ac.jp/Famsbase/）的全基因组orf构建了尽可能完整的比较蛋白结构模型集。对数据的统计分析也发表了。少

Mainly through the following research products and activities for three years, we conducted the maintenance and circulation of protein higher-order structural information and the evaluation of prediction information.Every year we held the open workshop of "Genome Information Science Based on Protein Higher-order Structures (Higher-order Genome)", including poster presentations of the "Higher-order Genome" group and a one-day symposium. In the first year, we invited two overseas speakers from the field of protein architecture and bioinformatics and held an international symposium. In the second year, in preparation for coming days of higher-order structural information flood according to rapid progress of the structural genomics, we held the open symposium titled "Information Biology as Structural Genome Science--When All Protein Structures of the Representative Proteins Are Clarified--", enhancing cooperation with structural biologists. Decoding of genome information would be incomplet … More e without understanding of proteins, main actors playing direct roles for physiological phenomena, and simulation studies are occupying an important position as a means for that aim. In the third year, we thus held the international symposium titled "Frontier Bioinformatics--To What Extent Can Simulations Clarify Protein Functions?", where four overseas researchers were invited."One-day symposium of computational structural genomics" was also held as a satellite meeting of "International Conference on Structural Genomics (ICSG) in 2000. Additionally, we executed various activities including research meetings of the "Higher-order Genome" group, support of young researcher's study meetings, travel support to attend the international meeting of "Critical Assessment of Techniques for Protein Structure Prediction (CASP)" and cooperation with alga researchers in "Genome Biology".On the other hand, we constructed as complete sets of comparative protein structure models as possible for the whole genome ORFs presented in GTOP database and publicly released as FAMSBASE (http://daisy.nagahama-i-bio.ac.jp/Famsbase/). A statistical analysis of the data was also published. Less