Utility of Innovative Artificial Oxygen Carriers for Diseases Derived From Circulatory Derangements

我们评估了新开发的人工氧载体（AOCs），如脂质体包裹血红蛋白（LEH），血红环糊精，卟烯肌红蛋白，在循环疾病引起的各种病理条件的动物模型中。这些AOCs，特别是LEH，已被证明对脑、耳蜗和骨骼肌缺血和/或再灌注损伤的器官功能和形态结构具有保护作用。LEH被证明在加速胃和皮肤伤口愈合方面是有效的。LEH在重建人类免疫系统的小鼠体内静脉输注也显示出惰性和安全性。大量LEH（20 mL/kg）输注后，小鼠免疫功能保持完整，对第三方抗原反应正常，这可能会竞争性地抑制宿主的抗原加工活性。

We evaluated newly developed artificial oxygen carriers(AOCs), such as liposome-encapsulated hemoglobin(LEH), hemocyclodextrin, corphysene-myoglobin, in the animal models of various pathologic conditions derived from circulatory disorder. These AOCs, specifically LEH, have been proved to be protective of the organ function and morphologic structure in ischemia and/or reperfusion injury of the brain, cochlea and skeletal muscle. LEH is shown to be effective in accelerating wound healing in the stomach and skin. LEH is also shown to be inert and safe on intravenous infusion in mice reconstituted with human immune system. The mice remains immunologically intact and normally responding against third party antigens after transfused with a large amount of LEH(20 mL/kg), which may competitively inhibit the antigen processing activity of the host.