Benetzung mit Polymer-Lipid-Verbundmembranen und Funktionalisierung von Festkörpern

该项目的主要目标是将亲水性多糖（c.f，葡聚糖，透明质酸，壳聚糖等）锚定在“毛棒”聚合物Langmuir-Blodgett （LB）膜的均匀和横向图案的功能表面上。在控制湿度的条件下，主要通过最近开发的成像微椭偏仪来研究聚合物薄膜（以及聚合物/脂复合材料的后期）的膨胀行为。“毛发杆”LB薄膜作为“功能平台”，可以实现(i)各种生物聚合物（受体、酶）在表面上的共价锚定，（ii）控制薄膜厚度以优化椭偏对比度，（iii）通过光刻技术构建聚合物薄膜，以及（iv）通过光化学技术实现功能化。主要的科学目标是：(1)通过测量膜厚度作为H2O化学势的函数来估计接枝到“毛状棒”上的各种生物聚合物的分子间电位(2)研究接触角、湿润液滴的形状和功能模式的滞后(3)测量脂质膜的粘附性(单层、双层、以及结构聚合物薄膜上的囊泡作为细胞-组织相互作用的模型

The primary goal of this project is to anchor hydrophilic polysaccharides (c.f., dextran, hyaluronic acid, chitosan, etc.) onto homogeneous and laterally patterned functional surfaces of Langmuir-Blodgett (LB) films of 'hairy-rod' polymers. The swelling behavior of the polymer films (and of polymer / lipid composite in a later stage) is mainly studied by a recently developed imaging microellipsometry under controlled humidity conditions.The 'hairy-rod' LB films as 'functional platforms' enable (i) covalent anchoring of various biopolymers (receptors, enzymes) onto the surfaces, (ii) control of film thickness to optimize ellipsometric contrast, (iii) structuring of polymer films by photolithography, and (iv) functionalization by photochemical techniques. Adhesion of vesicles onto the structured surfaces is monitored by the reflection interference contrast microscopy (RICM)Main scientific goals are:(1) Estimation of intermolecular potentials of various biopolymers grafted onto 'hairy-rods' by measuring film thicknesses as a function of the chemical potential of H2O(2) Study of contact angles, shape of wetting droplets, and hysteresis on functional patterns(3) Measurement of adhension of lipid films (monolayer, bilayer, and vesicles) on structured polymer films as a model of cell-tissue interaction