Comparative Studies on Nutritional Causative and Preventive Factors of Cardiovascular Diseases

由于我们对高血压和中风动物模型的实验研究表明，这些心血管疾病可以受到营养因素的极大影响，即使在遗传易感的动物模型中也可以预防，我们从流行病学的角度分析了饮食习惯差异较大的不同社区的饮食因素与心血管疾病的关系，以检验我们的实验结果对心血管疾病的适用性。这项比较研究的特点是其全球性，应用客观方法测量血压和生物标志物评估钠，钾，动物和植物蛋白的膳食摄入量，和脂肪酸，以及测量所有样品的井-研究人群为北京、石家庄、上海、广州和拉萨5个人口规模超过2000人的社区， ...更多信息 中华民国，其中随机选择健康男性和女性，共30名，年龄在50-54岁，进行24小时尿液收集，血压测量，血液采样和人体测量。将血液和尿液样本冷冻保存并运送至我们的分析中心，在那里通过火焰光度法和氨基酸分析仪分析尿液中的电解质和氨基酸。男性和女性的平均血压差异很大，北京（137/92，140/84）、拉萨（135/90，148/95）和石家庄（133/81，131/79）较高，上海（109/65，120/67）和广州（108/67，105/64）较低。尿盐排泄量除广州市为5.7g外，其余地区均高于13-15 g/d。收缩压和舒张压与尿钠的相关系数（r=0.789，0.652）或Na/K比值（r=0.572，0.444），但与牛磺酸/肌酐（r=-0.866，-0.815）或牛磺酸/3-甲基组氨酸比值（-0.871，-0.882）均具有显著性，提示含牛磺酸蛋白质的膳食如鱼粉在中国人群中具有降血压作用，正如我们之前的实验研究所证明的那样。少

Since our experimental studies on animal models for hypertension and stroke indicate that these cardiovascular diseases can be greatly affected by nutritional factors and be prevented even in genetically-predisposed animal models, we have analyzed epidemiologically the relationship between dietary factors and cardiovascular diseases in various communities where dietary customs were greatly different from each other to test the applicability of our experimental findings to the nutritional prevention of cardiovascular diseases in man. This comparative study is characterized with its global nature, application of objective methods to measure blood pressure and of biological markers to evaluate dietary intakes of Na, K, animal and vegetable proteins, and fatty acids as well as the measurement of all samples by well-standardized techniques at one laboratory.Study populations were 5 communities with population size over 2000 in Beijing, Shijiazhuang, Shanghai, Guangzhou and Lhasa in People's … More Republic of China, from which healthy males and females, 30 in total, at the age of 50-54 were randomly selected for 24-hour urine collection by aliquot cups, blood pressure measurement by an automated blood pressure measurement system, blood sampling and anthropometric measurements. Blood and urine samples were kept frozen and shipped to our analysis center, where electrolytes and amino acids in the urine were analyzed flamephotometrically and by an amino acid analyzer. The average blood pressure in males and females were widely varied, higher in Beijing (137/92, 140/84), Lhasa (135/90, 148/95) and Shijiazhuang (133/81, 131/79), and lower in Shanghai (109/65, 120/67) and Guangzhou (108/67, 105/64). Urinary salt excretion was generally higher 13-15 g per day except for Guangzhou with the excretion of 5.7 g. Coefficients of correlation of systolic and diastolic blood pressure with urinary Na (r=0.789, 0.652) or Na/K ratio (r=0.572, 0.444) were not significant but those with taurine/creatinine (r=-0.866, -0.815) or taurine/3-methylhistidine ratio (-0.871, -0.882) were significant, thus indicating the blood pressure lowering effect of dietary taurinecontaining protein such as fish meal in the Chinese populations, as previously proved by our experimental studies. Less