Study on the new functional neurotransmision image with PET in intact brain

In vivo binding？teristics ofイD13イD1H-raclopride，イD13イD1H-NMSP，イD13イD1H-NMPB，イD13イD1H-QNB，イD13イD1H-FMZ andイD1125イD1I-IMZ in mouse brain were investigated。伊D13伊D1 H-raclopride，伊D13伊D1 H-NMPB and伊D13伊D1 H-FMZ binding were much more sensitive to competitive inhibition than伊D13伊D1 H-NMSP，伊D13伊D1 H-QNB and伊D1125伊D1 I-IMZ binding， respectively。关于另一方，Yy D13 Yy D1 H-NMSP，Yy D13 Yy D1 H-QNB和Yy D1125 Yy D1 I-IMZ发现了更多敏感的药理学挑战，这些药物被认为是与flunitrazepam、MK-801、抗抑郁剂、rolipram和吗啡的治疗。这些结果表明，与相同的目标接收器结合使用了两种不同的放射性元素，它们可能具有很大的价值，以产生一个新的功能性信号传输图像。D111 D1C-FMZ和D111 D1C-IMZ在相同的rhesus monkey brain被执行了的动态PET扫描，以及一种新的图像类型，其中包括了D111 D1C-IMZ绑定的扩散边界。Dynamic PET scans of D113型D1N-ammonia and D115型D1O-water in the same rhesus monkey brain were also measured。在胶质细胞中，谷氨酸合成酶转化率的新图像已经被发现。对Y D13 Y D1 H-QNB和Y D13 Y D1 H-SCH 23390绑定的明显积极合作的初步研究;在植入大脑中可以特别观察到，也可以进行调查。

In vivo binding characteristics of ィイD13ィエD1H-raclopride, ィイD13ィエD1H-NMSP, ィイD13ィエD1H-NMPB, ィイD13ィエD1H-QNB, ィイD13ィエD1H-FMZ and ィイD1125ィエD1I-IMZ in mouse brain were investigated. ィイD13ィエD1H-raclopride, ィイD13ィエD1H-NMPB and ィイD13ィエD1H-FMZ binding were much more sensitive to competitive inhibition than ィイD13ィエD1H-NMSP, ィイD13ィエD1H-QNB and ィイD1125ィエD1I-IMZ binding, respectively. On the other hand, ィイD13ィエD1H-NMSP, ィイD13ィエD1H-QNB and ィイD1125ィエD1I-IMZ were found to be more sensitive to indirect effects induced by pharmacological challenges such as treatments with flunitrazepam, MK-801, antidepressants, rolipram and morphine. These results indicated that combined use of two different kinds of radioligands with the same target receptors might be of great value to make a new functional signal transmission image. Dynamic PET scans of ィイD111ィエD1C-FMZ and ィイD111ィエD1C-IMZ in the same rhesus monkey brain were performed, and a new type of image which included the diffusion boundary for ィイD111ィエD1C-IMZ binding was obtained. Dynamic PET scans of ィイD113ィエD1N-ammonia and ィイD115ィエD1O-water in the same rhesus monkey brain were also measured. The new image of the converting rate of glutamine synthetase in grial cell was obtained. Preliminary study on the apparent positive cooperativity of ィイD13ィエD1H-QNB and ィイD13ィエD1H-SCH23390 binding; which can be particularly observed in intact brain, was also investigated.