Synthesis of Highly Selective Polymer Materials with Solid-Solution Phases and Multiphase-Structure Analysis under Functioning State

以1，6-脱水叠氮糖为起始原料，通过一系列反应合成了在区域选择性位置上含有磺酰胺基和硫酸酯基的葡聚糖型多糖。磺酰胺组与硫酸盐组的抗凝活性基本相同，并有降低急性毒性的作用。以<alpha>1，4-脱水核糖和木糖为原料，经开环聚合得到1，5-呋喃型多糖，并对其进行硫酸酯化，得到硫酸化呋喃型多糖。这些类肝素显示出迄今为止制备的类肝素中最高的抗凝活性。用普通核磁共振和二维核磁共振谱以及元素分析对合成多糖和硫酸化多糖进行了结构分析，确定了硫酸基的位置。 ...更多信息 高效液相色谱法所得氯甲基化聚苯乙烯珠粒可在宽pH范围内使用。此外，通过选择合适的烷基链长，如采用&lt;C_（14）&gt;固定相，可以实现卤代苯和烷基苯的选择性分离。在相转移催化剂存在下，用亚硝酸钠对交联聚氯甲基苯乙烯进行功能化，得到含羧基和羟基的交联聚氯甲基苯乙烯，合成了热致芳香族聚酯和低分子量模型化合物。它们由芳香族介晶基元和柔性亚烷基间隔基组成。本文用固体CP/MAS ~（13）C NMR谱分析了大部分难溶于溶剂的芳香族聚酯的结构。在低温下制备的聚酯中，键合在芳环上的烷氧基具有固定的取向，这为具有优异力学性能的液晶聚合物的分子设计提供了指导。少

Dextran-type polysaccharides containing sulfamide and sulfate groups at regio-selective positions were synthesized by a series of reactions starting from the ring-opening polymerization of 1,6-anhydro-azido sugars. The sulfamide group exhibted almost the same anticoagulant activity as that of the sulfate group, and the former had a function to decrease the acute toxicity <LD_(50)> . 1,5- <alpha> -Linked furanan-type polysaccharides which were prepared by the ring-opening polymerization of 1,4-anhydro-ribose and -xylose were sulfated to give sulfated furanan-type polysaccharides. These heparinoids showed the highest anticoagulant activity of the so-far prepared heparinoids. The structure analysis of synthetic polysaccharides and sulfated ones was performed by using ordinary NMR and 2D NMR spectroscopy as well as the elemental analysis, indicating the position of sulfate group.Chloromethylated polystyrene beads were reacted with various alkylamines to provide the stationary phase of high … More perfomance liquid chromatography. The obtained chloromethylated polystyrene beads can be used in a wide pH range. In addition, the selective separation of halobenzenes and alkylbenzenes was possible by properly choosing the alkyl chain length, for example, by using a <C_(14)> stationary phase. Functionalization of crosslinked poly(chloromethylstyrene) beads was carried out by the reaction with sodium nitrite in the presence of phase transfer catalyst to afford the beads having carboxyl and hydroxyl groups.Thermotropic aromatic polyesters and low-molecular-weight model compounds were synthesized. They consisted of aromatic mesogens and flexible alkylene spacers. The structure of aromatic polyesters most of which were hardly soluble in solvents were analyzed with solid state CP/MAS <^(13)C> NMR spectroscopy. In the polyester prepared at low temperature, the alkoxy group bonded to the aromatic ring had a fixed orientation, which provides a guide to the molecular design of liquid crystalline polymers with excellent mechanical properties. Less