Wound healing-hypertrophic scar and scar contracture

本文观察了三只日本猕猴皮肤的创伤愈合过程和肥大细胞群的变化，发现猴大腿皮肤的刃厚擦伤创面，瘢痕形成迅速，有一段时间呈现增生性瘢痕的特征。炎症和增生性瘢痕的特征迅速消失，虽然这可能是由于人类和猴子之间的寿命差异。另一方面，据报道，小实验动物，如小鼠，大鼠和兔子，不产生任何增生性瘢痕。因此，可以说，猴子在伤口愈合过程中处于人类和这些小实验动物之间，在伤口愈合早期的皮肤活检标本中，发现肥大细胞数量减少，但在接近炎症改变的区域逐渐增加，尤其在炎症的最后阶段，表明瘢痕中结缔组织体积的增加与肥大细胞的数量之间存在某种关系。

The wound-healing process and change of mast cell population were studied in the skin of three Japanese monkeys.In the split-thickness abraded wound of the skin in the monkey thigh, the scar developed quickly and there was a period when it took on features that can be described both clinically and histopathologically as characteristic of hypertrophic scars. The inflammation and features of hypertrophic scar disappeared rapidly, although this may be due to the difference in life span between humans and monkeys.On the other hand, it has been reported that small experimental animals, such as mice, rats and rabbits, do not develop any hypertrophic scars. Therefore, it can be said that the monkey stands between humans and these small experimental animals insofar as the healing process of wound is concerned.In skin biopsy specimens at the early stage of the wound healing, the number of mast cells was found to have decreased, but it increased gradually in the area close to the inflammatory changes and showed a marked increase at the final stage of inflammation in particular.These findings suggest that there is some relationship between the increase in the volume of the connective tissue in scars and the number of mast cells.