Study on Comparative Molecular Epidemiology on Life Span, Cansese of Diseases, Genetical Factors and Geographical Environmental Factors Among Okinawan Immigrants, Comparing With Native Okinawan

通过对巴西、玻利维亚等地日本移民健康状况的研究，并与当地日本人（冲绳、岩手、秋田）的饮食习惯等环境因素进行比较，发现血清游离氨基酸（17种氨基酸）水平反映了日本移民与当地日本居民的饮食习惯特点。采用高效液相色谱法对健康体检时居住在1）玻利维亚冲绳居民区、2）巴西Saopaulo市、3）冲绳石川市、4）岩手县二户町、5）秋田横手市的健康受试者的个体氨基酸水平进行分析，并对每个受试者组的血清游离氨基酸进行相关性、判别分析和其他多变量分析。各氨基酸组分的相关矩阵结果显示，各组中性氨基酸水平之间具有较高的相关系数。

The study of health situation among Japanese immigrants in Brazil, Bolivia, comparing with native Japanese in three prefectures (Okinawa, Iwate and Akita) have contributed to elucidate environmental risk factors, such as eating habits.This report showed that the level of serum free amino acids (17 Kinds of amino acids) reflected the characteristics of eating habits between the Japanese immigrants and Japanese residents. The levels individual amino acid were analyzed by high-performance liquid chromatography for healthy subjects residing in 1) settlement Okinawa, Bolivia, 2) Saopaulo city, Brazil, 3) Ishikawa city, Okinawa, 4) Ninohe town, Iwate, 5) Yokote city, Akita at the time of health check up.Correlation, discriminant analysis and other multi-variant analysis of serum free amino acids from each subjects groups were performed. These results of correlation matrix of each amino acid components showed high correlation coefficients between the levels of neutral amino acids in each subject groups.