Comparative study of cytogenetic and molecular findings in lymphoid malignacies among Japan, USA, China and India

日本非霍奇金淋巴瘤（NHL）的发病率是美国的一半。本研究旨在了解日本和印度滤泡性淋巴瘤和慢性淋巴细胞白血病的发病率，并与西方国家的数据进行比较，同时对这些国家的细胞遗传学和分子遗传学结果进行调查。滤泡性淋巴瘤的比较研究1。滤泡性淋巴瘤占恶性淋巴瘤的比例在印度和日本约为10%，与美国相比非常低. 115例日本滤泡性淋巴瘤患者中有6例（40%）显示14 ; 18易位，4例印度患者中无一例。滤泡性淋巴瘤易位的比例也很低，与美国（85%）相比. 11例日本滤泡性淋巴瘤中，Southern印迹法检测到5例（45%）发生了BCL-2重排，PCR法检测到日本滤泡性淋巴瘤中的11.1%和印度滤泡性淋巴瘤中的9.7%发生了BCL-2重排。 ...更多信息 石蜡块NA。同样，与美国相比，这两个国家的发病率非常低。慢性淋巴细胞白血病（CLL）的比较研究1。48例日本CLL病例中有23例（47.9%）发现细胞遗传学异常。12号染色体三体仅占17.4例。这些低发生率与美国完全不同。10名印度人和5名中国人正在进行染色体分析。在55例日本慢性淋巴细胞白血病（CLL）患者中检测了BCL-1、BCL-2和BCL-3基因重排，其中BCL-1和BCL-3基因重排各1例，BCL-2基因重排2例。2例BCL-2基因重排分别为t（2 ; 18）（p12 ; q21）和t（18 ; 22）（q21 ;11）。前者表现为IgLK链与BCL-2基因之间以首尾相连的方式重排，后者表现为IgL λ链与BCL-2基因之间以首尾相连的方式重排。来自印度的16例和来自中国的5例正在进行分子遗传分析调查。少

The incidence of non-Hodgkin's lymphoma(NHL) in Japan is one-half of that in the USA. The present study was under taken to understand the incidence of follicular lymphoma and chronic lymphocyte leukemia in Japan and India in comparison to the data from the western countries, and also to investigate among these countries in cytogenetic and molecular genetic findings.Comparative study of follicular lymphoma1. The percentage of follicular lymphoma among the malignant lymphoma seemed to be about 10 in India and Japan, which is very low, comparing to that of USA.2. Six out of 115(40%) Japanese cases with follicular lymphoma showed 14 ; 18 translocation, none of four Indian cases. The percentage of follicular lymphoma cases with the translocation was also very low, comparing to that of USA (85%).3. BCL-2 rearrangement was observed in 5 of 11 (45%) Japanese cases with follicular lymphoma by Southern blot tiny method and 11.1% in Japanese cases and 9.7% in Indian cases by PCR method from the D … More NA of paraffin block. Again, these incidence in both countries were very low, comparing to that of USA.Comparative study of chronic lymphocytic leukemia (CLL)1. Cytogenetic abnormalities were found in 23 of 48 (47.9%) Japanese CLL cases. Trisomy 12 was found in only 17.4 of the cases analyze. These low incidences were completely different from that of USA. Ten Indian and 5 Chinese cases were under examination for chromosome analysis.2. The rearrangement of BCL-1, BCL-2 and BCL-3 were investigated in 55 Japanese CLL cases, of which one case each with BCL-1 and BCL-3 rearrangement and 2 with BCL-2 rearrangements were observed. The two cases with BCL-2 rearrangement had t(2 ; 18)(p12 ; q21) and t(18 ; 22)(q21 ;11), respectively. The former showed rearrangement between IgLK chain and BCL-2 gene in manner of gead to tail joining, the latter showed IgLlambda chain and BCL-2 gene in a manner of head to head joining. Sixteen cases from India and 5 from China are under investigation for molecular genetic analysis. Less