Pathophysiological Research of Cochlear efferent System

1)本文用耳声发射（OAEs）作为耳蜗功能的客观指标，对传出神经系统紊乱时的耳蜗生理进行了研究。作为第一步，声学测量系统的已知的4类OAE的构建。在这一系列的研究中，许多自发的OAE信号，从豚鼠，一直被认为是非常罕见的现象，仔细检查。描述并发表了豚鼠SOAE的基本特征。2）作为本课题在起始耳建立的声学测量系统的应用，对正常耳和听力受损耳进行了畸变产物（DP）OAE的测量。DP听力图被证明是耳蜗功能完整性的良好指标。它提供耳蜗生理的频率特异性信息。然而，DP测听不足以说明耳蜗病理的特定起源。进一步的调查似乎是必要的，我们可以提取这样的信息，从DP测听。

1)Investigation of cochlear physiology under derangement of efferent control system was conducted using otoacoustic emissions(OAEs)as an objective measure of the cochlear function. As the first step, an acoustic measuring system for known 4 classes of OAEs was constructed. In this series of research, many spontaneous OAE signals from guinea pigs, that had been regarded as extremely rare phenomenon, were closely examined. Basic features of guinea pig SOAEs were described and published. Efferent system did not look to affect on the SOAE in this animal.2)As an application of the acoustic measuring system which was established in the starting ear of the project, the distortion-product(DP)OAE was measured in normal and hearing-impaired ears. The DP audiogram was proved to be an excellent indicator of cochlear functional integrity. It provides frequencyspecific information of the cochlear physiology. However, the DP audiometry was not powerful enough to specify particular origin of a cochlear pathology. Further investigation seemed to be necessary before we can extract such an information from the DP audiometry.