A new nutrition with the knowledges of life science and molecular biology

利用生命科学和分子生物学的前沿进行新型营养的研究。它包括营养摄入与细胞增殖和分化的相互作用、发育过程中的基因表达、营养物质消化吸收的调节、人体的内分泌和外分泌以及防御系统等。在脂肪组织中发现前脂肪细胞生长因子。并且，研究了视黄酸抑制前脂肪细胞生长的机制（Sugimoto）。本文研究了自发性高血压大鼠（SHR）和部分品系大鼠对氯化钠和酒精的偏爱反应。动物蛋白质喂养的大鼠准备酒精，并发现一些氨基酸参与了反应（木村）。盲肠对膳食纤维降胆固醇作用的重要性（桐山）。研究了幼鼠肠道apo A-IV mRNA的调节，并阐明了一些重要因素（Sugano）。发现肝脏原代培养基中必需氨基酸对IGF-I和血清白蛋白的mRNA稳定化（Noguchi）。进行CCK释放肽的分子克隆（Fushiki）。详细研究了抗坏血酸缺乏对肝脏中药物代谢酶和胆固醇代谢的影响（Yoshida）。

Studies of new style of nutrition were performed with a cutting edge of a life science and molecular biology. It includes the interaction between nutrition intake and cell proliferation and differentiation, gene expression during development, regulation of digestion and absorption of nutrients, endocrinology and exocrinology and defense system of human beings.In the course of the project, following new results in the nutrition fields were obtained. Preadipocyte growth factor was found in the adipose tissue. And ,mechanisms on retinoic acid depress the growth of the preadipicytes were figured out (Sugimoto). SHR and some strains of rats were investigated in the preference response to NaCl and alcohol. Animal protein fed rats prepered to alcohol, and found that some amino acid involved in the response (Kimura). Importance of the caecum for the cholesterol-lowering effect of dietary fibers (Kiriyama). Regulation of intestinal apo A-IV mRNA in rat pups was investi gated and some serious factors were elucidated (Sugano). mRNA stabilization of IGF-I and serum albumin by essential amino acids in the primary culture medium of liver was found (Noguchi). Molecular cloning of CCK-releasing peptide was performed (Fushiki). Effects of ascorbic acid deficiency on the drug-metabolizing enzymes in liver and cholesterol metabolism was studied in detail (Yoshida).