A New Platform for Developing a Compound Against Herpes Simplex Virus
A New Platform for Developing a Compound Against Herpes Simplex Virus
批准号:
LP150100314
负责人:
Prof Fariba Dehghani
金额:
$34.09万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-03-15 至 2020-12-31
中文摘要
该项目旨在进一步探索研究小组最近在澳大利亚鲍鱼中发现的一种天然蛋白质的基本发现,该蛋白质通过阻断三种关键的病毒糖蛋白来抑制病毒进入。我们的目标是利用这些知识开发一种新的针对单纯疱疹病毒(HSV)及其后续感染的治疗方法。新的治疗方法可以克服目前药物的低生物利用度,从而显着缩短复发期。这些新药可能具有广泛的适用性。
英文摘要
This project aims to further explore the research team’s recent fundamental discovery of a protein found naturally in an Australian abalone that inhibits viral entry by blocking three key viral glycoproteins. We would aim to utilise this knowledge towards development of a new class of therapeutics against Herpes simplex viruses (HSV) and their consequent infections. The new therapeutics could overcome the low bioavailability of current drugs and thus significantly shorten the recurrence period. Such new drugs may have broad applicability.
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