Synthesis and Structure-Function Studies of the Glycoprotein Adiponectin

该项目旨在了解碳水化合物修饰对脂肪细胞衍生激素脂联素的结构和功能的作用，脂联素已显示出对肥胖，2型糖尿病和心血管疾病的保护作用。提高对调节脂肪的分子机制的认识对于解开这些疾病的发展过程至关重要。该项目计划使用新的合成技术来访问脂联素库，该库具有连接到肽骨架的定义的碳水化合物模式，从而可能详细剖析这些修饰对结构，细胞信号传导和胰岛素增敏活性的作用。

This project aims to understand the role of carbohydrate modifications on the structure and function of the fat cell-derived hormone adiponectin, which has shown protective effects against obesity, type 2 diabetes and cardiovascular disease. Advancing knowledge of the molecular mechanisms that regulate fat is crucial to unravelling the processes involved in the development of these diseases. The project plans to use novel synthetic technologies to access a library of adiponectins with defined patterns of carbohydrates attached to the peptide backbone, thus potentially enabling detailed dissection of the role of these modifications on structure, cell signalling and insulin sensitising activities.