Management of Post-operative Pain after Day Case Surgery

罗匹安注射液是氟比洛芬的前体药物，对前列腺素的生物合成有强烈的抑制作用。它是由脂肪乳化型氟比洛芬酯制成的非甾体静脉镇痛剂。静脉给药时，它在体内会迅速分解为氟比洛芬。它出色的止痛作用使其对普通手术后的疼痛和与各种癌症相关的疼痛有效。当手术在局部麻醉下进行时，口服药物可能令人满意，但当患者在静脉镇静或全身麻醉下治疗时，这些药物通常不适合，尤其是在口腔手术后。因此，本研究旨在探讨罗匹恩注射液对口腔手术后疼痛的疗效。40例术后疼痛难以忍受的患者，随机分为两组：20例在静脉镇静下拔除磨牙，20例在全身麻醉下接受矢状劈开截骨术。给药后每隔10分钟用100 mm视觉模拟标尺评估疼痛，持续2小时。结果表明，罗匹恩注射剂对控制口腔手术后疼痛非常有效，所有患者在给药后10-70分钟后疼痛几乎消失。

ROPION^<<O!>> Injection is a pro-drug of flurbiprofen which strongly inhibits biosynthesis of prostaglandin. It is an non-steroidal intravenous analgesic agent prepared by fat-emulsifying flurbiprofen axtil. When administered intravenously, it is rapidly hydrolyzed into flurbiprofen in the body. Its excellent analgesic actions make it effective against post-operative pain for general surgery and pain associated with various types of cancer.When surgery is performed under local anaesthesia, oral drugs may be satisfactory, but when patients are treated under intravenous sedation or general anaesthesia these are generally unsuitable, especially just after oral surgery. Therefore this study was designed to investigate the effect of ROPION^<<O!>> Injection for post-operative pain of oral surgery.40 patients, who were administrated intravenously 50 mg of flurbiprofen axtil in one dose when they declared unendurable post-operative pain, were randomly entered into the study : 20 patients received the surgical removal of molars under intravenous sedation, 20 patiens received the sagittal split osteotomy under general anaesthesia. Pain was assessed every 10 minutes for 2 hours after the administration using a 100 mm visual analogue scale.The results showed that ROPION^<<O!>> Injection was very useful to control post-operative pain after oral surgery, and that the post-operative pain almost disappeared from 10 to 70 minutes after the administration in all patients.