Disease models and novel diagnostic imaging markers

该项目旨在开发新的非侵入性方法来检测和监测突触功能障碍背景下的突触损伤。新的自身抗体/--从患者来源的免疫细胞中产生的新的自身抗体/片段将被用于通过脑内或全身抗体注射产生神经精神疾病的小鼠模型。这些模型将被用来验证基于铁/格拉络合物标记的自身抗体的全新化合物。经过改造的抗体可以在体内显示突触的变化。这个项目的中心问题是如何利用新开发的基于抗体的成像探针来通过分子磁共振在体内可视化和量化突触功能障碍。

This project aims at the development of novel non-invasive ways to detect and monitor synaptic damage in the context of synaptic dysfunction. Novel autoantibodies/-fragments generated within the consortium from patient-derived immune cells will be used to generate mouse models of neuropsychiatric disease by intracerebral or systemic antibody injections. The models will be used to validate entirely new compounds based on autoantibodies labelled with iron/gadolinium complexes. The engineered antibodies may allow the in vivo visualization of synaptic changes. The central question of this project is how newly developed antibody-based imaging probes can be utilized for the in vivo visualization and quantification of synaptic dysfunction by molecular magnetic resonance.