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Magnetic particle imaging: Development and evaluation of novel methodology for the assessment of the aorta in vivo in a small animal model of aortic aneurysms

磁粒子成像：开发和评估小动物主动脉瘤模型体内主动脉评估的新方法

基本信息

批准号：
312920752
负责人：
Professor Dr. Marcus R. Makowski
金额：
--
依托单位：
Institut für diagnostische und interventionelle Radiologie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/312920752?language=en
关键词：
Magnetic particle imaging Development evaluation

项目摘要

Compared to other imaging modalities, e.g. magnetic resonance imaging (MRI), MPI allows for 3D imaging of magnetic particles with a significantly higher sensitivity and temporal resolution. Preliminary results using MPI have shown the potential of this novel technology to perform angiographies. The proposed project will build on the DFG major equipment action that has funded a preclinical MPI scanner in Berlin. The aim of this project is: 1) to develop novel image acquisition and reconstruction techniques for MPI to improve the acquisition of angiographies and the quantification of iron oxide particle uptake in vessel wall. 2) to test these novel acquisitions techniques in an animal model of aortic aneurysm. In particular the spatial and temporal resolution of MPI will be validated. Additionally, we will evaluate whether MPI can accurately quantify iron oxide particles that accumulate in the arterial wall, on early and delayed scans (e.g. 24 hours after administration of particles). We will compare the performance of MPI with MRI to characterize aortic aneurysms and quantify iron oxide uptake by MR relaxometry and susceptibility mapping. All in vivo results will be validated ex vivo using reference methods including histology and mass spectroscopy.

与其他成像模式（例如磁共振成像（MRI））相比，MPI允许以显著更高的灵敏度和时间分辨率对磁性颗粒进行3D成像。使用MPI的初步结果显示了这种新技术进行血管造影的潜力。拟议项目将建立在DFG主要设备行动的基础上，该行动已资助柏林的临床前MPI扫描仪。本项目的目的是：1）开发用于MPI的新型图像采集和重建技术，以改善血管造影的采集和血管壁中氧化铁颗粒摄取的定量。2)在主动脉瘤动物模型中测试这些新的采集技术。特别是MPI的空间和时间分辨率将得到验证。此外，我们将评估MPI是否可以在早期和延迟扫描（例如，颗粒给药后24小时）中准确定量动脉壁中积聚的氧化铁颗粒。我们将比较MPI与MRI的性能，以描述主动脉瘤的特征，并通过MR弛豫法和磁敏感性绘图量化氧化铁的摄入。所有体内结果将使用参考方法（包括组织学和质谱法）进行离体验证。