Joint study on nutritional epidemiology of breast cancer

为了揭示饮食因素在印度尼西亚女性乳腺癌中的作用，自1992年以来在雅加达开展了一项病例对照研究，包括营养访谈。截至1996年1月底，收集了226个病例和452个对照者的流行病学和营养资料。初步分析揭示了以下发现。(a)每卡路里摄入的蛋白质、脂肪、钙、磷、视黄醇和抗坏血酸越多，患乳腺癌的风险就越高。尤其在脂肪摄入方面发现了显著的正相关。相对于第一个四分位数，第二、第三和第四四分位数的比值比（ORs）分别为2.66、4.28和5.52（趋势p=2*10^<-9>）。(b)相反，每卡路里的碳水化合物摄入量与风险呈强烈负相关；相应的or值分别为0.73、0.45和0.20（趋势p=3*10^<-9>）。这些结果，以及我们之前使用食物频率法的病例对照研究结果表明，过量的脂肪摄入可能会增加印度尼西亚女性患乳腺癌的风险。

In order to disclose the role of dietary factors in female breast cancer in Indonesia, a case-control study has been undertaken including a nutritional interview in Jakarta since 1992. Epidemiological and nutritional information was collected for 226 cases and 452 controls as of the end of January, 1996. The preliminary analysis revealed the following findings. (a) The more the intake (per calorie) of protein, fat, calcium, phosphorus, retinol and ascorbic acid, the higher the risk of breast cancer. Remarkable positive association was detected particularly for fat intake. The odds ratios (ORs) for the second, third and fourth quartile, relative to the first quartile, were 2.66,4.28 and 5.52, respectively (trend p=2*10^<-9>). (b) In contrast, carbohydrate intake per calorie was strongly and negatively associated with the risk ; the corresponding ORs being 0.73,0.45 and 0.20, respectively (trend p=3*10^<-9>). These results, along with the findings obtained by our previous case-control study which used a food frequency method, suggest that excess fat intake may increase breast cancer risk in Indonesian females.