JOINT STUDY ON BIOCHEMICAL PROCESSES WITH INTEGRATED UNITS

为了满足各行业日益增长的需求，迫切需要开发有效的新型生物聚合物的生物生产和纯化工艺，如医用多肽、抗生素、工程蛋白和各种酶。该项目的主要目标是通过交流不同的思想和专家，建立有效和先进的生产和分离装置。日本大阪大学高分子与化学研究所(TCL),乙。本项目利用了局部功能材料、膜、脂质体、双水相体系等。它还包括基于流动动力学分析的复杂生物反应器的构建，反应器的设计和控制，以及过程的优化。本国际研究项目的研究成果有助于生物分离策略和新型生物反应器系统的基础和技术进步，以培养微生物和动植物细胞，并减少环境负荷。另一个重要成果是通过调查两国教育和研究系统的最新信息，为大学学者和工业工程师做出贡献。

The development of effective bioproduction and purification processes of the new biopolymers, such as medically useful peptides, antibiotics, engineered proteins and various enzymes, has been urgently needed to meet the increasing demands in various industries.The major objective of this project was to establish effective and advanced units of production and separation through the exchange of different ideas and experts in the institutions, Dept. of Chem.Sci.Eng., Osaka University, Institute for Polymer and Chem.Eng.Dept. (TCL), ETH.This project exploited topical functional materials, membranes, liposomes, aqueous two-phase systems etc. It also included the construction of sophisticated bioreactors based on the analyzes of flow dynamics, design and control of reactors, and optimization of the processes.The obtained findings from this international research project contributed to the basic and technological progress of bioseparation strategies and novel bioreactor systems to cultivate microbes and animal or plant cells, and also to minimize environmental loading. The other important outcome was to contribute to both university academics and industrial engineers by surveying up-to-date information on educational and research systems in both countries.