The role of water metabolism on the environmental adaptation

研究了不同环境的适应机制与水分平衡的关系。为这一项目聚集的科学家是这一领域的专家，他们处理受体机制、体积和渗透压受体、口渴和饮酒行为、交感神经控制肾功能、水平衡的中枢机制、水平衡与体温和循环调节的关系，以及水代谢的比较方面。这些科学家在本项目期间两次聚会，交流他们最近的研究进展和想法，并试图获得个人研究的整合。在本项目中报道的新发现如下：雌激素对AVP分泌细胞和AV3V细胞渗透敏感性的改变(Akaish和Honma)，肝脏Na受体在钠平衡前馈控制中的作用(Hosomi，Morita)，IL-1在饮酒行为控制中的作用，心血管和肾脏功能(Kannan)，连续测定血液密度和血清电解质分析体液移动(Shiraki)，ANP家族的比较分析(CNP、BNP、VNP)及其在进化中的意义(Takei)，控制AVP分泌的中枢神经网络(Negoro)，PVN和SON神经元渗透接受的细胞机制(Ysamashita)，脑脊髓渗透压与皮肤循环的控制(Nose)，以及体液容量和渗透压对循环和体温调节的影响(Morimoto)。在11月29-30日举行的会议上，对成员研究人员的结果进行了综合讨论，每个与会者都同意未来此类合作的必要性。

Adaptive mechanisms to various environments were studied in relationship with water balance. The scientist gathered for this projects were experts in this field, and deal with receptor mechanisms, volume and osmolar receptors, thirst and drinking behavior, sympathetic control of renal function, central mechanisms of water balance, the relationship between water balance and regulations of body temperature and circulation, and comparative aspects of water metabolism. These scientists gather twice during the term of this projects, and exchanged their recent progress of their research and ideas, and tried to obtain the integration of individual research.New findings reported during this projects are as follows : Modification of osmosensitivity of AVP secretory cells and AV3V cells by estrogen (Akaish & Honma) , the role of liver Na-receptor in the feedforward control of Na balance (Hosomi, Morita) , the role of IL-1 in the control of drinking behavior, cardio-vascular and kidney function (Kannan) , analysis of body fluid shift with continuous determination of blood density and serum electrolytes in response to headout water immersion (Shiraki) , comparative analysis of ANP-family (CNP,BNP,VNP) and its significance in evolution (Takei) , central neuronal network for the control of AVP secretion (Negoro) , cell mechanisms of osmoreception by PVN and SON neurons (Ysamashita) , cerebrospinal osmolality and control of cutaneous circulation(Nose), and the effects of body fluid volume and osmolality on the control of circulation and body temperature regulation (Morimoto).At the meeting held on November 29-30, synthesis of the results from member investigators were discussed, and each participant agreed with the necessity of this kind of cooperation in future.