Study related to the exercise and the non-specific immunity in middleaged and elder

通过观察急性和习惯性运动对老年人非特异性免疫的影响，量化运动对老年人非特异性免疫的改善作用。结果表明：1 -不进行常规运动的老年人，急性-轻度有氧运动60min以上可增加氧化爆发；2-每天以50% VO2max强度进行60分钟的常规运动可改善老年人的氧化爆发（横断研究结果）：3- 5周及以上的最佳运动训练对提高有氧工作能力是必要的，10周及以上的最佳运动训练可增强老年人的非特异性免疫，特别是中性粒细胞的吞噬能力。检测了习惯性、适度运动（慢跑、骑自行车、网球等）对T / b淋巴细胞（T-/ b细胞）和NK细胞分布的影响。淋巴细胞计数和t细胞/ b细胞比值在青年（20-39岁）、中年（40 -59岁）和老年（60岁*）三个年龄组之间无显著差异。在先天免疫成分中，nk细胞浓度不随年龄、意志、运动习惯的变化而变化，但中性粒细胞的氧化爆发和吞噬作用在老年运动者中比在老年久坐者中相对增加。研究了定期进行适度运动（如慢跑、骑自行车、网球或游泳）的非锻炼者和适度锻炼者的日常心理压力与免疫能力之间的关系。将男性志愿者分为青年（20-39岁）、中年（40-59岁）和老年（60岁*）三个年龄组，并考察代际差异。结果表明，适度的运动可以减轻应激水平，从而使个体的免疫状况得到改善。应激对照中CD8+杀伤/抑制性t细胞水平升高可能是由于应激激素的增加，并可能抑制其他效应细胞功能，特别是在年轻一代中。少

The effects of acute and habituation of exercises on non-specific immunity in aged were examined to quantify the opilimal exercise for improving the immunity. The results indicates that : 1 - the acute-mild-aerobic exercise for more than 60 min increases oxidative burst in aged who are not performing a regular exercise ; 2- the regular exercise at 50% VO2max intensity for 60 min per day improves the oxidative burst in aged (resluts from the cross sectional study) : 3- five and more weeks of optimal exercise training is necessary for improving aerobic work capacity, and 1O and more weeks for enhancing nonspecific immunity, especially, phagocytosis of neutrophils in aged.The effects of habitual, moderate exercises (jogging, cycling, tennis, etc.) on the distribution of T-/B-lymphocytes (T-/B-cells) and NK cells were tested. Lymphocyte counts and T-cell/B-cell ratio were not different among the three age groups : young (20-39yr), middle-aged (4O-59yr) and elderly (6Oyr*). In the component … More s on innate immunity, the concentration on NK-cell was not altered with age, not will, habitual exercise, but the oxidative burst and phagocytosis of neutrophils showed a relative increase in the elderly exercisers as compared with the elderly sedentary subjects.The relationship between daily psycological stress estimated by the STAI score and immunocompetence in non exercisers and moderate exercisers who were regularly practicing moderate exercise, such as jogging, cycling, tennis or swimming were investigated. Male volunteers were separated into three age groups : young (20-39yr), middle-aged (40-59yr) and elderly (60yr*), and the generation differences were also examined. The results indicate that the moderate exercise may mitigate the stress level, leading to a better immunological condition of the individual. The higher level of CD8+killer/suppressor T-cells in the stressful controls may be due to an increase of stress hormones and may suppress other effector cell functions, especially in the younger generations. Less