NON-INVASIVE STUDY OF HUMAN BRAIN FUNCTION USING PHYSIOLOGICAL METHODS,MAGNETOENCEPHALOGRAPHY AND ELECTROENCEPHALOGRAPHY

我们研究了躯体感觉(SEF)和视觉(VEF)刺激后的磁场(EF)，以探讨人脑中感觉知觉的时空信息机制。SEF我们记录了施加于头皮、嘴唇、上肢和下肢的电或机械刺激后的SEF，并再次证实了Penfield博士报道的初级感觉区(SI)中的“小人”。总体上，感受野与“小人”一致，但个体间存在较大差异，特别是在小腿区，也存在个体内差异。我们制作了一种新的装置来产生“被动运动”，以研究大脑皮层对通过肌肉传入上升的信号的活动。手指被动活动后的波形和激活区域与施加在手指上的电或机械刺激后的波形和激活区域都有显著不同。可能差异是由于FAC…造成的被动运动激活SI内3a区的TS较多，电刺激或机械刺激后则激活SI内3b区。我们采用模式颠倒黑白棋盘刺激法记录VEF，主要研究初级视皮层对不同视野刺激的激活区域。首先，我们使用了半象限的视野刺激，并确认视网膜桥与VI中激活区的分离相对应。这一发现与所谓的“十字形模型”一致。接下来，我们记录中枢和外周野刺激后的VEF。VEF对中央场的刺激主要位于枕叶顶部。VEF很难记录这些领域的活动。与之相比，VEF对周围野的刺激以较大幅度清晰地记录到。我们记录了开腹运动的VEF，发现在颞下沟升支与枕外侧沟交叉点附近有活动，被认为是V5/MT区。这是首次在人类中发现V5/MT。较少

We studied magnetic evoked fields (EF) following somatosensory (SEF) and visual (VEF) stimulation to investigate the mechanisms of sensory perception in terms of temporal and spatial information in the human brain.SEFWe recorded SEF following electrical or mechanical stimulation applied to the scalp, lip, upper limb and lower limb, and reconfirmed "homunculus" in the primary sensory area (SI) reported by Dr. Penfield. In general, receptive fields are consistent with "homunculus", but a large inter-individual difference was found, particularly in the lower limb area in SI.We also found the intra-individual (left-right) difference. We made a new device to produce "passive movement" to investigate cortical activities to the signals ascending through muscle afferent. Both waveforms and activated areas following passive movement of fingers were significantly different from those following electrical or mechanical stimulation applied to the fingers. Probably the difference was due to the fac … More ts that are 3a in SI was activated follwoing a passive movement, but area 3b in SI was activated following electrical or mechanical stimulation.VEFWe used pattern-reversal black and white checker board stimulation to record VEF,mainly to investigate the activated areas in the primary visual cortex (VI) to various visual fields stimulation. At first, we used a half and quadrant field stimulation and confirmed that the retinotopy corresponded to the separation of activated areas in VI.This finding was consistent with a so-called "cruciform model". Next, we recorded VEF following central and peripheral field stimulation. VEF to the central field stimulation was mainly located in the crown of the occipital lobe. It is difficult for VEF to record activities in such areas. In contrast, VEF to the peripheral field stimulation was clearly recorded with a large amplitude. We recorded VEF to the aparent motion, and found activities around the crossing point of the ascending branch of the inferior temporal sulcul and lateral occipital sulcus, being considered to be V5/MT area. This was the first reort to identify V5/MT in humans. Less