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Investigation of human pain perception, mainly on the second pain ascending-through C fibers.

对人类疼痛感知的研究，主要是通过 C 纤维上行的第二疼痛。

基本信息

批准号：
15016104
负责人：
KAKIGI Ryusuke
金额：
$ 22.91万
依托单位：
Department of Integrative Physiology National Institute for Physiological Sciences (2004)Okazaki National Research Institutes (2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15016104/
关键词：
Pain Electroencephalography Magnetoencephalography Human Somatosensory Electrodes Laser Touch microneurography first pain second pain 睡眠

项目摘要

We have been studying human pain perception using electroencephalography (EEG) and magnetoencephalography (MEG), since they have an excellent temporal resolution in order of msec. MEG is more useful to detect activated areas following painful stimulation, because the spatial resolution of EEG is not very high. For recording activities following A delta fiber stimulation relating to the first pain, painful CO2 laser stimulation is now widely used, but our new method, epidermal stimulation (ES), is also very useful. The primary small activity was recorded from the primary somatosensory cortex (SI), probably in area 1, in the hemisphere contralateral to the stimulation. Then, secondary somatosensory cortex (SII) and insula were activated with the second activity in SI. These 3 regions were activated in parallel with almost the same time period. This is a very characteristic finding in pain perception. Then, the cingulate cortex and medial temporal area (MT) around the amygdala and hippocampus were activated. In the hemisphere ipsilateral to the stimulation as well, the above regions were activated, except for SI. Therefore, we speculated that SI plays a main role in localization of the stimulus point, the SII and insula are important sites for pain perception, and the cingulate and MT are mainly responsible for cognitive or emotional aspects of pain perception. For recording activities following C fiber stimulation relating to the second pain, we recently developed a new method, that is, applying weaker CO2 laser stimuli to tiny areas of the skin. MEG findings following C fiber stimulation were also similar to those following A delta fiber stimulation. However, the effects of sleep and attention on MEG following C fiber stimulation were much larger than that following A delta fiber stimulation. This finding may suggest greater effects of cognitive or emotional functions on second pain than the first pain.

我们一直在使用脑电图（EEG）和脑磁图（MEG）研究人类疼痛感知，因为它们具有毫秒级的出色时间分辨率。 MEG 对于检测疼痛刺激后的激活区域更有用，因为 EEG 的空间分辨率不是很高。为了记录与第一次疼痛相关的 A δ 纤维刺激后的活动，目前广泛使用疼痛性 CO2 激光刺激，但我们的新方法表皮刺激 (ES) 也非常有用。主要的小活动是从初级体感皮层 (SI) 记录的，可能位于刺激对侧半球的区域 1。然后，次级体感皮层（SII）和岛叶被 SI 中的第二次活动激活。这三个区域几乎在同一时间段同时激活。这是疼痛感知的一个非常典型的发现。然后，杏仁核和海马周围的扣带皮层和内侧颞区（MT）被激活。在刺激同侧的半球中，除了 SI 之外，上述区域也被激活。因此，我们推测SI在刺激点的定位中起主要作用，SII和岛叶是疼痛感知的重要部位，扣带回和MT主要负责疼痛感知的认知或情感方面。为了记录与第二次疼痛相关的 C 纤维刺激后的活动，我们最近开发了一种新方法，即对皮肤的微小区域施加较弱的 CO2 激光刺激。 C 纤维刺激后的 MEG 结果也与 A δ 纤维刺激后的结果相似。然而，C 纤维刺激后睡眠和注意力对 MEG 的影响远大于 A δ 纤维刺激后的影响。这一发现可能表明认知或情感功能对第二次疼痛的影响比第一次疼痛更大。