Investigation of mechanisms for human pain perception and its clinical application, mainly on function of signals ascending through C fibers.

研究人类疼痛感知机制及其临床应用，主要研究通过C纤维上行的信号功能。

基本信息

批准号：
15390480
负责人：
KAKIGI Ryusuke
金额：
$ 7.04万
依托单位：
National Institute for Physiological Sciences (2004-2005)Okazaki National Research Institutes (2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

OBJECTIVE : We studied electrophysiological studies using electroencephalography (EEG), magnetoencephalography (MEG) and repetitive transcranial magnetic stimulation (rTMS) as well as functional magnetic resonance imaging (fMRI) on human pain perception.METHODS : For recording activities following A delta fiber stimulation relating to first pain, several kinds of lasers such as CO2, Tm : YAG and argon lasers are now widely used. The activity is frequently termed laser evoked potential (LEP). We also developed new method, epidermal stimulation (ES), which is useful for recording brain activities by the signals ascending through A delta fibers. For recording activities following C fiber stimulation relating to second pain, several methods have been used but weak CO2 laser stimuli applied to tiny areas of the skin were recently used.RESULTS : EEG and MEG findings following C fiber stimulation were similar to those following A delta fiber stimulation except for a longer latency. We also studied the effect of rTMS on acute pain perception. rTMS alleviated acute pain induced by intracutaneous injection of capsaicin, which activated C fibers, but it enhanced acute pain induced by laser stimulation, which activated A delta fibers. As for fMRI studies, thalamus, secondary somatosensory cortex (SII), insula and cingulate cortex in the bilateral hemispheres were activated following both A delta and C fiber stimulation. However, only a small region, area 6/8/32 and pre supplementally motor area (SMA) were selectively activated following C fiber stimulation.DISCUSSION : In addition to the above methods, one promising approach in the near future is to analyze the change of a frequency band. This method will probably be used for evaluation of continuous tonic pain such as cancer pain, which evoked response studies cannot evaluate.

目的：我们使用脑电图（EEG），磁脑电图（MEG）和重复的经颅磁刺激（RTM）以及人类疼痛感知的功能磁共振成像（FMRI）研究了电生理研究。现在广泛使用激光。该活性通常称为激光诱发电位（LEP）。我们还开发了新方法，表皮刺激（ES），这对于通过三角洲纤维上升的信号记录大脑活动很有用。对于与第二次疼痛有关的C纤维刺激后的记录活动，最近使用了几种方法，但最近使用了用于皮肤小区域的二氧化碳激光刺激。分子：C纤维刺激后的EEG和MEG发现与延长延长延长的Delta纤维刺激后的EEG和MEG发现相似。我们还研究了RTM对急性疼痛感知的影响。 RTMS减轻了辣椒素激活C纤维引起的急性疼痛，但它增强了激光刺激引起的急性疼痛，从而激活了Delta纤维。至于功能磁共振成像研究，丘脑，次生体感皮层（SII），在三角洲和C纤维刺激后激活了双侧半球中的绝缘皮层和扣带回皮层。然而，在C纤维刺激后，仅选择性地激活了一个小区域，即6/8/32和补充运动前区域（SMA）。识别：除了上述方法外，在不久的将来，一种有希望的方法是分析频带的变化。该方法可能会用于评估连续的强直疼痛（例如癌症疼痛），诱发反应研究无法评估。