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Physiological investigation of pain perception in humans

人类疼痛感知的生理学研究

基本信息

批准号：
03807049
负责人：
KAKIGI Ryusuke
金额：
$ 1.22万
依托单位：
Okazaki National Research Institute (1993)佐賀医科大学 (1991-1992)
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

项目摘要

We investigate pain-related somatosensory evoked potentials follwing CO_2 laser stimulation (pain SEPs) to elucidate the mechanisms of pain perception in humans. We caluculated conduction velocity (CV) of small myelinated fibers (Adelta) and the spinothalamic tract which pain sensation ascends through by using pain SEPs.CV of both of them were about 10 m/sec.We investigated machanisms of change of pain perception induced by various modalities of sensation in normal subjects. Concurrently applied vibratory stimuli to and active movements of fingers significantly reduced and prolonged pain SEPs, but continuous cooling did not. The findings were consistent with gate control theory (Melzack & Wall). Pain SEPs were also significantly attenuated by voluntary and passive movements of remote areas such as the foot. This finding was not produced by vibration or movement imagery of the limbs without active movement. Therefore, interactions between pain perception and movement-related cortical activities must take place in some areas of the brain without relieving pain.We studied pain SEPs in patients with various neurological diseases such as peripheral neuropathies, syringomyelia, multiple sclerosis (MS) and HTLV-I-associated myelopathy (HAM). Results of pain SEps showed a significant correlation with a degree of pain impairment. In addition, subclnical lesions could be detected by pain SEPs in MS and HAM.Pain SEPs were very useful for clinical testing, particularly when we recorded and analyzed both pain SEPs and conventional electrically-stimulated SEPs.

我们研究了CO_2激光刺激后与疼痛相关的体感诱发电位（pain sep），以阐明人类疼痛感知的机制。我们用痛觉电位计算了痛觉上升经过的小髓鞘纤维（Adelta）和脊髓丘脑束的传导速度（CV）。两者的CV都约为10m /s。我们研究了正常受试者在不同感觉模式下疼痛知觉变化的机制。同时应用振动刺激和手指的主动运动显著降低和延长疼痛sep，但持续冷却没有。研究结果与门控制理论（Melzack & Wall）一致。自发性和被动运动的远端区域，如足部，疼痛sep也显著减弱。这一发现并不是由没有主动运动的肢体的振动或运动图像产生的。因此，疼痛感知和运动相关的皮层活动之间的相互作用必须发生在大脑的某些区域，而不缓解疼痛。我们研究了各种神经系统疾病患者的疼痛sep，如周围神经病、脊髓灰质炎、多发性硬化症（MS）和htlv - i相关脊髓病（HAM）。疼痛sep结果显示与疼痛损害程度显著相关。此外，MS和HAM的疼痛sep可以检测到亚临床病变。疼痛性sep对临床测试非常有用，特别是当我们记录和分析疼痛性sep和常规电刺激性sep时。