INVESTIGATION OF HUMAN BRAIN FUNCTION USING MICRO-SQUID.

使用微型鱿鱼研究人脑功能。

• 批准号: 09558102
• 负责人: KAKIGI Ryusuke
• 金额: $ 7.04万
• 依托单位: OKAZAKI NATIONAL RESEARCH INSTITUTE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09558102/
• 关键词: Micro; SQUID; Magnetoencephalography; MEG; Resolution; Brain function; Vision; Somatosensory; 脳磁図; 脳波; SQUID; 言語; 顔; 痛覚; 磁場; 末梢神経; 脳機能; 超小型; 脊髄

We developed a new multi (twelve) - channel gradiometer system with the smallest and highest quality superconducting quantum interference device (micro-SQUID). A very small distance (3.80 mm) between the sensor coils and the skin provides quite high spatial resolution. Since this was the newly-developed machine, at first, we had to solve many small problems in terms of hardware, software, and magnetic shielded room. Finally, it took approximately 2 and a half years to solve all problems. Then we started the experiments from 1999.The first study was published in Neurosciecne Letters in 1999 concerniong peripheral nerve function. The actual whole image of the sensory nerve action fields (NAF) of the human median nerve at the wrist were successfully recorded following digital nerve stimulation by using the micro-SQUID.The NAF showed the biphasic waveform at each of the 12 channels, and the isomagnetic field map clearly showed the moving quadrupole pattern. The quadrupole comprised a dipole for depolarization followed by another dipole with the opposite direction for repolarization. The polarized length of the nerve obtained by reconstructing the magnetic field maps was approximately 17 cm, and the magnetic field complex moved along the nerve from the distal to the proximal part of the wrist at 58.7 m/s.

我们研制了一种新的多（十二）通道梯度系统的最小和最高质量的超导量子干涉器件（micro-SQUID）。传感器线圈和皮肤之间的非常小的距离（3.80 mm）提供了相当高的空间分辨率。由于这是新开发的机器，起初，我们必须解决硬件，软件和磁屏蔽室方面的许多小问题。最后，花了大约两年半的时间解决了所有问题。1999年，第一个关于周围神经功能的研究发表在1999年的Neurosciecne Letters。用微型SQUID记录了人腕部正中神经电刺激后的感觉神经动作场（NAF）的完整图像，NAF在12个通道上均呈双相波形，等磁场图清晰地显示了运动四极图。四极包括用于去极化的偶极子，随后是用于复极化的具有相反方向的另一偶极子。通过重建磁场图获得的神经的极化长度约为17 cm，磁场复合体以58.7 m/s的速度沿神经从腕部的远侧部向近侧部沿着移动。

项目成果

Maeda K, Kakigi R, et al: "Mapping of receptive fields in the secondary somatosensory cortex in humans : a magnetoencephalographic study"NeuroReport. 10. 301-306 (1999)

Maeda K、Kakigi R 等人：“人类次级体感皮层感受野的映射：一项脑磁图研究”NeuroReport。

Watanabe S, Kakigi R, et al: "Human face perception traced by magneto- and electro- encephalography"Brain Research Cognitive Brain Research. 8. 125-142 (1999)

Watanabe S、Kakigi R 等人：“通过磁磁和脑电图追踪人脸感知”大脑研究认知大脑研究。

Kakigi R et al: "The somatosensory evoked magnetic fields."Progress in Neurobiology. 61. 495-523 (2000)

Kakigi R 等人：“体感诱发磁场。”神经生物学进展。

Nakamura A, Kakigi R: "Somatosensory homunculus as drawn by MEG" Neuroimage. 7.3. 377-386 (1998)

Nakamura A、Kakigi R：“MEG 绘制的体感小人”神经图像。

Kakigi R: "Watanabe S. : Pain-related Somatosensoryevoked potentials following CO_2 laser stimulation."Pain Forum. 7. 185-187 (1998)

Kakigi R：“Watanabe S.：CO_2 激光刺激后与疼痛相关的体感诱发电位。”疼痛论坛。