Development of artificial intervertebral disc

人工椎间盘（AID）的发展用于恢复脊柱的稳定性和可动性是可取的。我们研制的聚乙烯醇水凝胶（PVA-H）与钛纤维网（TFM）复合材料作为人工骨软骨材料，似乎是AID的最佳候选材料。在本研究中，我们比较了犬椎间盘和PVA-H椎间盘的各种力学特性，以期为AID的发展提供基础数据。在本研究中，最适宜用于AID的PVA-H的含水量在30% ~ 45%之间。我们将上述材料制成的12个人工椎间盘植入12只beagle犬的L4-L5椎间盘。术后3个月的肉眼和显微镜检查显示该材料与椎体的附着非常好，材料周围的组织学表现良好。综上所述，这种复合材料在艾滋病治疗中具有很好的应用前景。

Development of an artificial intervertebral disc (AID) for use in restoring both the stability and movability of the spine is desirable. The composite materials, made of polyvinyl alcohol hydrogels (PVA-H) and titanium fiber mesh (TFM) which we had developed as an artificial osteo-chondral material seems to be the best candidate for AID.In this study, we compared various mechanical properties of canine intervertebral disc and those of PVA-H in order to obtain fundamental data for development of AID.The best competent PVA-H for AID in this study had water content between 30% and 45%. We implanted 12 artificial intervertebral discs made of above-described material into L4-L5 intervertebral disc of 12 beagle dogs. Macroscopic and microscopic findings 3 months after the operations revealed very good attachment of this material to vertebral bodies and good histological findings around the materials. In conclusion, this composite material is very promising candidate for use in AIDs.