Development of novel membrane type artificial lung having controlled surface morphology

采用阴离子活性聚合技术制备了含有机硅的聚苯乙烯/聚(甲基丙烯酸羟乙酯)嵌段共聚物。所得嵌段共聚物具有独特的热力学性质。尤其是嵌段含量仅为10ﾟ%的嵌段共聚物具有很低的玻璃化转变温度(Tg=10ﾟC)，而两个链段的玻璃化转变温度都很高(150和70 kgC)。共聚物链的高柔韧性导致了极高的血液相容性。由于在每个单体单元中引入了两个有机硅基团，所获得的嵌段共聚物不仅在干条件下表现出高的气体交换能力，而且在湿条件下也表现出高的气体交换能力。用这种嵌段共聚物在PP微孔膜上构建了一种既具有血液相容性又具有高透气性的高性能膜。

Organosilicon-containing polystirene/poly (2-hydroxyethyl methacrylate)block copolymers were prepared by an anionic living polymerization technique. The obtained block copolymer showed unique thermodynamic properties. Especially, the block copolymer which possess only 10 mol% of poly (Si-stirene) segment showed very low glass transition temperature (Tg=10ﾟC) though both segments exhibit the fairly high Tgs (150 and 70ﾟC). The high flexibility of the copolymer chain caused extremely high blood compatibility. The obtained block copolymers also shows high gas exchange ability not only dry but also wet conditions due to the introduction of two organosilicon groups in each monomer unit. By construction of this film using this block copolymer on PP microporous membrane, the high performance membrane which possess both blood compatibility and high gas permeability was obtained.