Pathophysiology of diastolic dysfunction in hypertrophied hearts-Role of myocyte cytoskeleton-

1)微管在心肌肥厚过程中对心肌细胞收缩功能障碍的作用由于心肌持续的压力超负荷，在左室肥厚过程中微管密度的进行性增加可能导致随后的心肌细胞收缩功能障碍。2）微管在心肌粘弹性中的作用微管的改变也可能影响多细胞组织制备物中收缩力的形成，这可能使我们能够将在细胞水平上获得的发现扩展到体内心室收缩性能。微管增多也可导致心肌粘度增加。因此，微管在心肌收缩中具有特殊的重要性，因为这些元件的改变可以很好地解释肥厚心肌中观察到的性能变化。

1) Role of microtubules for the myocyte contractile dysfunction during cardiac hypertrophyThe progressive increase of microtubule density during LV hypertrophy due to persistent pressure overloading to the myocardium may cause the consequent myocyte contractile dysfunction.2) Role of microtubules in the viscoelastic properties of the myocardiumMicrotubule alterations could also affect the contractile force development in the multicellular tissue preparations, which might allow us to extend the findings obtained at the cellular level to the ventricular contractile performance in vivo. The increased microtubules conld also contribute to the increased viscosity of the myocardium. Therefor, microtubules are of especial importance in cardiac muscle contractility because the alterations of these elements might well explain the performance changes noted in the hypertrophied myocardium.