Gallium, Copper and Metal Fluoride Complexes Designed for Brain Imaging

该项目旨在开发基础合成配位化学，旨在开发用于正电子发射断层扫描脑血流成像的新试剂。这项研究将集中在开发含有铜、镓和氟的正电子发射同位素的新的配位络合物。目标是将这些放射性核素结合成小分子，用于大脑的分子成像。这种化学将有可能取代现有的技术，这些技术依赖于氚的单光子发射和单光子发射计算机断层扫描技术。

This project aims to develop fundamental synthetic coordination chemistry directed toward the development of new agents for imaging brain perfusion using positron emission tomography. The research will focus on developing new coordination complexes containing positron-emitting isotopes of copper, gallium and fluorine. The goal is incorporate in these radionuclides into small molecules that can be used for the molecular imaging of the brain. This chemistry will have the potential to replace existing technologies that rely on single-photon emission from technetium and the technique of single photon emission computed tomography.