Development of new antimicrobial pressure sensitive adhesive polymer for surgical tape

首先，我们利用植物过氧化物酶（POD）的高自由基氧化活性来合成各种抗菌化合物。我们成功地通过POD偶联反应从愈创木酚、异丁香酚、阿魏酸、咖啡酸、百里酚、香芹酚和羟基芪酚等酚类化合物中制备了几种抗菌化合物。其中，我们选择了异丁香酚的POD反应产物作为进一步的实验的抗菌化合物。接下来，我们准备了几种用于手术胶带的粘合剂聚合物原型。我们使用以下聚合物如HPAO、PANTA、PAOB和NITTO作为基础粘合剂聚合物。将POD反应产物在甲苯中在基础聚合物上方混合以产生用于涂覆到聚合物载体上的掺杂混合物。涂布后，通过干燥箱干燥制剂以除去溶剂。我们研究了药物浓度对其抗菌活性的影响，并阐明了超过10%的药物含量对于表达抗菌活性至关重要。实际上，含有20%异丁香酚活性药物的粘合剂聚合物对金黄色葡萄球菌显示出明显的抗菌活性。我们认为，异丁香酚POD产物的疏水性导致其对介质的渗透性较低，并研究了在粘合聚合物中加入表面活性剂的影响。然而，添加表面活性剂如Tween 20或Tween 8O引起聚合物聚集。我们推测这是由于非离子表面活性剂与芳香族多价异氰酸酯交联剂反应的结果。总之，PAOB和PANTA是作为本研究的基础聚合物的良好候选物。应进一步研究交联剂。

At first, we paid an attention to high radical oxidizing activity of peroxidase (POD) from plant to synthesize various antimicrobial compounds. We succeeded to prepare several antimicrobial compounds derived from several phenolics such as guaicol, isoeugenol, ferulic acid, caffeic acid, thymol, carvacrol and hydroxystilben via POD coupling reaction. Among them, we chose a POD reaction product derived from isoeugenol as an antimicrobial compound for further experiments. Next, we prepare several prototypes of adhesive polymer for surgical tapes. We used following polymers such as HPAO, PANTA, PAOB, and NITTO for base adhesive polymer. POD reaction products were mixed above base polymer in toluene to be yielded dope mixture for coating onto the polymer supports. After coating, the preparations were dried up by the drying oven to remove solvent. We examined effects of drug concentrations on their antimicrobial activities and clarified that more than 10% of drug content is essential for expression of antimicrobial activity. Actually, adhesive polymer containing 20% of active drug from isoeugenol show an apparent antimicrobial activity against Staphyrococuss aureus. We suggested that hydrophobicity of isoeugenol POD products cause its low permeability to medium and studied effects of surfactant addition into adhesive polymer. However, addition of surfactant such as Tween 20 or Tween 8O caused aggregation of polymer. We guess that above phenomena was caused from reaction between nonionic surfactant and aromatic multivalent isocyanic crosslinker. In conclusion, PAOB and PANTA were good candidates as base polymers for this study. Further investigation about crosslinker should be performed.