Mapping and defining inter-organ cross talk during exercise

这个项目旨在精确地研究器官是如何交流和相互作用的。这些相互作用在运动中尤为重要，当持续的运动需要复杂的器官交流时，随着年龄的增长，这些相互作用对整个生物体都有重大影响。这种交流是如何发生的尚不清楚，但我们现在知道，货物与细胞外囊泡（ev）的运动在器官间的交流中起着不可或缺的作用。该项目期望建立在我们在通过电动汽车进行器官间通信的生物学方面取得的前所未有的最新进展之上。预期的结果将对整个生命科学和生物技术产生广泛的影响。

This project aims to examine precisely how organs communicate and interact. These interactions are particularly important during exercise, when continued movement demands intricate organ communication, and have major ramifications for the whole organism as it ages. Precisely how this communication takes place is unclear, but we now know that the movement of cargo with extracellular vesicles (EVs) plays an integral role in organ to organ communication. This project expects to build upon unprecedented recent developments we have made in the biology of inter-organ communication via EVs. The expected outcomes will have broad impact across life science and biotechnology.