Role of heat shock proteins in oral mucosal diseases and focal in fection

热休克蛋白（HSP）是一种高度保守的免疫原性分子，由多种应激诱导产生。微生物和人类HSP之间的结构同源性被认为是慢性炎症性疾病中自身免疫的基础。采用ELISA法检测了掌跖脓疱病（PPP）患者血清中抗GloEL/GroES、BCG HSP 65和重组人HSP 60抗体水平。与健康对照组（n= 22，0.218（± SD））比较，P < 0.01。PPP患者血清抗GroEL/GroES IgG抗体水平升高（n=43，0.342 ± 0.176）。抗牛支原体HSP 65抗体与人重组HSP 60抗体之间无显著性差异（P> 0.05）。抗GroEL/GroES抗体水平与r-人HSP 60之间存在相关性。PPP作为一种局灶性感染性疾病，细菌HSP可能是其抗原，而人HSP 60不是其自身抗体。

Heat shock proteins (HSP) are highly conserved immunogenic molecules that are induced by a variety of stresses. Structural homology between microbial and human HSP has been postulated to be a basis for autoimmunization in chronic inflammatory diseases. We estimated by ELISA titration the antibody levels to GloEL/GroES,Mycobacterium bovis BCG HSP65 and recombinant human HSP60 in sera of patients with palmoplantar pustulosis (PPP). In comparison with healthy controls (n=22,0.218(]SY.+-。[)0.176), serum anti GroEL/GroES lgG antibodies were elevated in PPP (n=43, 0.342(]SY.+-。[)0.246, p<0.05), but anti M.bovis HSP65 and r-human HSP60 antibodies were not significant difference. There were a correlation between levels of anti GroEL/GroES antibody and r-human HSP60. In PPP, as a focal infectious disease, bacterial HSP might be a antigen, but human HSP60 not be autoantibody.